Car4-positive adipocyte progenitor cells adapt to the aging environment and work as protection against ROS via glutathione metabolism
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-17231-7
Abstract: The induction of beige adipocytes is significantly reduced in aged mice due to the senescence of adipocyte progenitor cells (APCs). Recent studies have revealed the existence of beige adipocyte subtypes, suggesting that APCs comprise a… read more here.
Keywords: adipocyte progenitor; adipocyte; car4 positive; aging environment ... See more keywords
Targeting nuclear receptor NR4A1–dependent adipocyte progenitor quiescence promotes metabolic adaptation to obesity
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Investigation"
DOI: 10.1172/jci98353
Abstract: Adipocyte turnover in adulthood is low, suggesting that the cellular source of new adipocytes, the adipocyte progenitor (AP), resides in a state of relative quiescence. Yet the core transcriptional regulatory circuitry (CRC) responsible for establishing… read more here.
Keywords: quiescence; receptor nr4a1; nuclear receptor; adipocyte progenitor ... See more keywords
Ciliary control of adipocyte progenitor cell fate regulates energy storage
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1083372
Abstract: The primary cilium is a cellular sensory organelle found in most cells in our body. This includes adipocyte progenitor cells in our adipose tissue, a complex organ involved in energy storage, endocrine signaling, and thermogenesis.… read more here.
Keywords: adipocyte progenitor; cell fate; progenitor; energy storage ... See more keywords