Adipocyte‐specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14335
Abstract: Adipose tissue regulates whole‐body energy homeostasis. Both lipodystrophy and obesity, the extreme and opposite aspects of adipose tissue dysfunction, result in metabolic disorders: insulin resistance and hepatic steatosis. Cyclin‐dependent kinases (CDKs) have been reported to… read more here.
Keywords: adipocyte specific; adipose tissue; dysfunction; specific cdk7 ... See more keywords
Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101202
Abstract: Objective Impaired circadian clocks can cause obesity, but their pathophysiological role in brown adipose tissue (BAT), a major tissue regulating energy metabolism, remains unclear. To address this issue, we investigated the effects of complete disruption… read more here.
Keywords: bmal1; brown adipocyte; bat; adipocyte specific ... See more keywords
Adipocyte-specific gp130 signalling mediates exercise-induced weight reduction
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DOI: 10.1038/s41366-019-0444-7
Abstract: Background Repetitive physical activity is a well-established intervention to reduce obesity and to prevent weight regain. Besides increased energy expenditure, reduced caloric intake may contribute to exercise-induced weight loss in obesity. Using adipocyte-specific glycoprotein 130… read more here.
Keywords: gp130 adipo; weight reduction; induced weight; adipocyte specific ... See more keywords
Adipocyte-Specific Laminin Alpha 4 Deletion Preserves Adipose Tissue Health despite Increasing Adiposity
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DOI: 10.3390/biomedicines10092077
Abstract: Laminins are heterotrimeric glycoproteins with structural and functional roles in basement membranes. The predominant laminin alpha chain found in adipocyte basement membranes is laminin α4 (LAMA4). Global LAMA4 deletion in mice leads to reduced adiposity… read more here.
Keywords: adipocyte specific; laminin alpha; deletion; adiposity ... See more keywords
Adipocyte-Specific ACKR3 Regulates Lipid Levels in Adipose Tissue
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9040394
Abstract: Dysfunctional adipose tissue (AT) may contribute to the pathology of several metabolic diseases through altered lipid metabolism, insulin resistance, and inflammation. Atypical chemokine receptor 3 (ACKR3) expression was shown to increase in AT during obesity,… read more here.
Keywords: specific ackr3; ackr3; adipocyte specific; tissue ... See more keywords