Adiponectin receptor agonist AdipoRon attenuates calcification of osteoarthritis chondrocytes by promoting autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29605
Abstract: Cartilage calcification contributes to the development and progression of osteoarthritis (OA). It has been well‐investigated adiponectin regulates vascular calcification. The purpose of this study is to investigate the therapeutic value and the molecular mechanism of… read more here.
Keywords: receptor agonist; osteoarthritis; calcification; adiporon ... See more keywords
Physical exercise attenuates age-related muscle atrophy and exhibits anti-ageing effects via the adiponectin receptor 1 signalling.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cachexia, sarcopenia and muscle"
DOI: 10.1002/jcsm.13257
Abstract: BACKGROUND Although the adiponectin signalling exerts exercise-mimicking effects, whether this pathway contributes to the anti-ageing benefits of physical exercise has not been established yet. METHODS Swim exercise training and wheel running were used to measure… read more here.
Keywords: exercise; anti ageing; muscle; physical exercise ... See more keywords
Telmisartan attenuates diabetic nephropathy progression by inhibiting the dimerization of angiotensin type‐1 receptor and adiponectin receptor‐1
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2019.01.044
Abstract: Aims: The heterodimerization of angiotensin II receptors (AT1R and AT2R) with adiponectin receptor AdipoR1 and AdipoR2 may instigate high glucose (HG)‐induced renal tubulointerstitial injury. This study examined the effect of telmisartan on diabetic nephropathy (DN)… read more here.
Keywords: dimerization; telmisartan; adiponectin receptor; diabetic nephropathy ... See more keywords
Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression
Sign Up to like & getrecommendations! Published in 2018 at "Translational Psychiatry"
DOI: 10.1038/s41398-018-0210-y
Abstract: Major depression is a psychiatric disorder with complex etiology. About 30% of depressive patients are resistant to antidepressants that are currently available, likely because they only target the monoaminergic systems. Thus, identification of novel antidepressants… read more here.
Keywords: depression; corticosterone; receptor agonist; adiponectin receptor ... See more keywords
Adiponectin receptor PAQR-2 signaling senses low temperature to promote C. elegans longevity by regulating autophagy
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10475-8
Abstract: Temperature is a key factor for determining the lifespan of both poikilotherms and homeotherms. It is believed that animals live longer at lower body temperatures. However, the precise mechanism remains largely unknown. Here, we report… read more here.
Keywords: adiponectin receptor; low temperature; paqr signaling;
Regulatory roles of adiponectin receptor 1 and 2 in sheep preadipocytes during adipocyte differentiation
Sign Up to like & getrecommendations! Published in 2019 at "Italian Journal of Animal Science"
DOI: 10.1080/1828051x.2019.1568838
Abstract: Abstract Adipose tissue has long been considered as an energy storage organ. Adipokines, produced by and secreted from adipose tissues, play an important role in regulating fat accumulation, energy balance, and glucose metabolism. Adiponectin receptors… read more here.
Keywords: expression; differentiation; sheep preadipocytes; adipocyte differentiation ... See more keywords
Adiponectin receptor agonist AdipoRon relieves endotoxin-induced acute hepatitis in mice
Sign Up to like & getrecommendations! Published in 2019 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000000488
Abstract: Abstract Background: Adiponectin is the most abundant adipokines that plays critical roles in the maintenance of energy homeostasis as well as inflammation regulation. The half-life of adiponectin is very short and the small-molecule adiponectin receptor… read more here.
Keywords: mice; acute hepatitis; adiponectin receptor; receptor agonist ... See more keywords
An adiponectin receptor agonist promote osteogenesis via regulating bone‐fat balance
Sign Up to like & getrecommendations! Published in 2021 at "Cell Proliferation"
DOI: 10.1111/cpr.13035
Abstract: Adiponectin signalling has been considered to be a promising target to treat diabetes‐related osteoporosis. However, contradictory results regarding bone formation were observed due to the various isoforms of adiponectin. Therefore, it would be necessary to… read more here.
Keywords: bone fat; bone; adiponectin receptor; adiponectin ... See more keywords
Regulation of the cardioprotective adiponectin and its receptor AdipoR1 by salt.
Sign Up to like & getrecommendations! Published in 2017 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2016-0570
Abstract: Both circulating adiponectin (APN) and cardiac APN exert cardioprotective effects and improve insulin sensitivity and mitochondrial function. Low circulating APN serves as a biomarker for cardiovascular risk. Ablation of adiponectin receptor 1 (AdipoR1) causes myocardial… read more here.
Keywords: receptor adipor1; salt; apn; adiponectin receptor ... See more keywords
Potent anti-inflammatory effects of the adiponectin receptor agonist, ALY688
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733710
Abstract: Low circulating levels of adiponectin are associated with increased inflammation in a wide-range of disease states. In particular, this applies to obesity-related diseases such as type 2 diabetes, heart failure and non-alcoholic fatty liver disease.… read more here.
Keywords: agonist aly688; anti inflammatory; physiology; inflammatory effects ... See more keywords
Adiponectin receptor activation with AdipoRon prevents Truvada-induced microvascular oxidative stress and dysfunction in mice
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734618
Abstract: Background: Persons living with the human immunodeficiency virus (PLHIV) and treated with anti-retroviral therapy such as emtricitabine and tenofovir disoproxil fumarate (Truvada, TVD) have increased cardiovascular risk but the mehcamisms and management are unclear. Since… read more here.
Keywords: adiponectin; microvascular oxidative; oxidative stress; physiology ... See more keywords