Adiponectin receptor agonist AdipoRon attenuates calcification of osteoarthritis chondrocytes by promoting autophagy
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DOI: 10.1002/jcb.29605
Abstract: Cartilage calcification contributes to the development and progression of osteoarthritis (OA). It has been well‐investigated adiponectin regulates vascular calcification. The purpose of this study is to investigate the therapeutic value and the molecular mechanism of… read more here.
Keywords: receptor agonist; osteoarthritis; calcification; adiporon ... See more keywords
PEGylated AdipoRon derivatives improve glucose and lipid metabolism under insulinopenic and high-fat diet conditions
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DOI: 10.1016/j.jlr.2021.100095
Abstract: The pleiotropic actions of adiponectin in improving cell survival and metabolism have motivated the development of small-molecule therapeutic agents for treating diabetes and lipotoxicity. AdipoRon is a synthetic agonist of the adiponectin receptors, yet is… read more here.
Keywords: fat diet; metabolism; adiporon; high fat ... See more keywords
Activating Adiponectin Signaling with Exogenous AdipoRon Reduces Myelin Lipid Accumulation and Suppresses Macrophage Recruitment after Spinal Cord Injury.
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DOI: 10.1089/neu.2018.5783
Abstract: Myelin-laden macrophages (mye-MΦ), resulting primarily from internalization of myelin debris by infiltrating bone marrow-derived macrophages in spinal cord injury (SCI), trigger inflammatory responses that largely contribute to secondary injury. Adiponectin, which is secreted from adipose… read more here.
Keywords: lipid accumulation; adiporon; myelin lipid; adiponectin ... See more keywords