Adiponectin receptor agonist AdipoRon attenuates calcification of osteoarthritis chondrocytes by promoting autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29605
Abstract: Cartilage calcification contributes to the development and progression of osteoarthritis (OA). It has been well‐investigated adiponectin regulates vascular calcification. The purpose of this study is to investigate the therapeutic value and the molecular mechanism of… read more here.
Keywords: receptor agonist; osteoarthritis; calcification; adiporon ... See more keywords
AdipoRon promotes angiogenesis in B-cell leukemia by modulating pro-angiogenic factors through AdipoR1
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Biology Reports"
DOI: 10.1007/s11033-025-11183-x
Abstract: Adiponectin, a cytokine predominantly secreted by adipose tissue, is increasingly recognized for its role in cancer, including hematologic malignancies. However, its involvement in leukemia-related angiogenesis remains poorly understood. Here, we investigated the effects of AdipoRon,… read more here.
Keywords: adiporon; angiogenesis; cell leukemia; leukemia ... See more keywords
PEGylated AdipoRon derivatives improve glucose and lipid metabolism under insulinopenic and high-fat diet conditions
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Lipid Research"
DOI: 10.1016/j.jlr.2021.100095
Abstract: The pleiotropic actions of adiponectin in improving cell survival and metabolism have motivated the development of small-molecule therapeutic agents for treating diabetes and lipotoxicity. AdipoRon is a synthetic agonist of the adiponectin receptors, yet is… read more here.
Keywords: fat diet; metabolism; adiporon; high fat ... See more keywords
Activating Adiponectin Signaling with Exogenous AdipoRon Reduces Myelin Lipid Accumulation and Suppresses Macrophage Recruitment after Spinal Cord Injury.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of neurotrauma"
DOI: 10.1089/neu.2018.5783
Abstract: Myelin-laden macrophages (mye-MΦ), resulting primarily from internalization of myelin debris by infiltrating bone marrow-derived macrophages in spinal cord injury (SCI), trigger inflammatory responses that largely contribute to secondary injury. Adiponectin, which is secreted from adipose… read more here.
Keywords: lipid accumulation; adiporon; myelin lipid; adiponectin ... See more keywords
Abstract 4142757: Adiponectin receptor agonist alleviates heart failure with preserved ejection fraction by regulating NLRP3/Caspase-1/IL-1β and Pl3K/Akt signaling pathway
Sign Up to like & getrecommendations! Published in 2024 at "Circulation"
DOI: 10.1161/circ.150.suppl_1.4142757
Abstract: Background: Treating and managing heart failure with preserved ejection fraction (HFpEF) remains challenging. With the gradual increase in the number of obese individuals, diabetics, and cases of hypertension, HFpEF prevalence accounts for half of the… read more here.
Keywords: adiporon; adiponectin receptor; heart; receptor agonist ... See more keywords
Adiponectin Receptor Agonist AdipoRon Inhibits Proliferation and Drives Glycolytic Dependence in Non-Small-Cell Lung Cancer Cells
Sign Up to like & getrecommendations! Published in 2024 at "Cancers"
DOI: 10.3390/cancers16152633
Abstract: Simple Summary NSCLC is one of the most life-threatening forms of oncological diseases. Although targeted and immunotherapy treatments have improved NSCLC prognosis, the chance of surviving is still limited for many patients. Therefore, further efforts… read more here.
Keywords: cancer; adiporon; non small; small cell ... See more keywords