DNA minor-groove binder Hoechst 33258 destabilizes base-pairing adjacent to its binding site
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DOI: 10.1038/s42003-020-01241-4
Abstract: Understanding the dynamic interactions of ligands to DNA is important in DNA-based nanotechnologies. By structurally tracking the dissociation of Hoechst 33258-bound DNA (d(CGCAAATTTGCG) 2 ) complex ( H-DNA ) with T-jump 2D-IR spectroscopy, the ligand… read more here.
Keywords: hoechst 33258; dna; binding site; base ... See more keywords