Transcriptomic data in tumor-adjacent normal tissues harbor prognostic information on multiple cancer types.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5864
Abstract: In identifying prognostic markers in cancer, the roles of tumor‐adjacent normal tissues are often confined to drawing expression differences between tumor and normal tissues rather than being treated as the main targets of investigations. Thus,… read more here.
Keywords: adjacent normal; tumor adjacent; normal tissues; data tumor ... See more keywords
Hypermethylated ZNF582 and PAX1 genes in oral scrapings collected from cancer-adjacent normal oral mucosal sites are associated with aggressive progression and poor prognosis of oral cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2017.11.013
Abstract: OBJECTIVE This study assessed whether hypermethylated ZNF582 and PAX1 genes in oral scrapings are correlated with the progression and prognosis of oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS Methylation levels of ZNF582 and PAX1… read more here.
Keywords: normal oral; mucosal sites; oral mucosal; adjacent normal ... See more keywords
Elevated miRNA Inversely Correlates with E-cadherin Gene Expression in Tissue Biopsies from Crohn Disease Patients in contrast to Ulcerative Colitis Patients
Sign Up to like & getrecommendations! Published in 2020 at "BioMed Research International"
DOI: 10.1155/2020/4250329
Abstract: Inflammatory bowel disease (IBD) comprises ulcerative colitis (UC) and Crohn disease (CD). Similar symptoms, but different treatment procedures for both diseases require precise diagnosis. MicroRNAs (miRNAs) are major posttranscriptional players that regulate the expression of… read more here.
Keywords: mir; disease; tissue; expression ... See more keywords
Individualized Breast Cancer Characterization through Single-Cell Analysis of Tumor and Adjacent Normal Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-3308
Abstract: There is a need to individualize assays for tumor molecular phenotyping, given variations in the differentiation status of tumor and normal tissues in different patients. To address this, we performed single-cell genomics of breast tumors… read more here.
Keywords: single cell; normal cells; adjacent normal; cancer ... See more keywords
High expression of tissue O-linked glycans is associated with a malignant phenotype of cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of International Medical Research"
DOI: 10.1177/0300060520976864
Abstract: Objective This study aimed to investigate the expression of O-linked glycoprotein glycans in tissue of patients with cholangiocarcinoma compared with adjacent normal tissue. Methods Sixty patients with cholangiocarcinoma were included in the study. Permethylated O-linked… read more here.
Keywords: linked glycans; tissue; patients cholangiocarcinoma; expression ... See more keywords
Microbiome landscape of lesions and adjacent normal mucosal areas in oral lichen planus patient
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.992065
Abstract: The pathogenesis of oral lichen planus (OLP) remains unclear, and microbial dysbiosis has been proposed to play a role in the pathogenesis of OLP. Oral mucosal swabs from 77 OLP patients and 76 healthy subjects… read more here.
Keywords: adjacent normal; mucosal; oral lichen; normal mucosal ... See more keywords
MicroRNA Profiling of Fresh Lung Adenocarcinoma and Adjacent Normal Tissues from Ten Korean Patients Using miRNA-Seq
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DOI: 10.3390/data8060094
Abstract: MicroRNA transcriptomes from fresh tumors and the adjacent normal tissues were profiled in 10 Korean patients diagnosed with lung adenocarcinoma using a next-generation sequencing (NGS) technique called miRNA-seq. The sequencing quality was assessed using FastQC,… read more here.
Keywords: lung adenocarcinoma; mirna seq; adjacent normal; normal tissues ... See more keywords
Alteration in Levels of Specific miRNAs and Their Potential Protein Targets between Human Pancreatic Cancer Samples, Adjacent Normal Tissue, and Xenografts Derived from These Tumors
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13030608
Abstract: Herein, we describe the global comparison of miRNAs in human pancreatic cancer tumors, adjacent normal tissue, and matched patient-derived xenograft models using microarray screening. RNA was extracted from seven tumor, five adjacent normal, and eight… read more here.
Keywords: pancreatic cancer; human pancreatic; adjacent normal; protein ... See more keywords
Genetic, epigenetic and transcriptional comparison of esophagus tumor-associated and adjacent normal myofibroblasts
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DOI: 10.3892/or.2018.6909
Abstract: Myofibroblasts (MFs) are present in healthy tissues and are also key components of the tumor microenvironment. In the present study a comparative analysis of MFs obtained from various gastrointestinal tumor tissues and from tumor-adjacent normal… read more here.
Keywords: tumor associated; present study; adjacent normal; mfs ... See more keywords
Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.25801
Abstract: As part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Repass et al., 2016), that described how we intended to replicate an experiment from the paper ‘Fusobacterium nucleatum infection is prevalent in… read more here.
Keywords: fusobacterium nucleatum; colorectal carcinoma; study; tissue ... See more keywords