Increased bodyweight and inadequate response to aspirin in individuals with coronary artery disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-019-01830-z
Abstract: Recent reports have suggested that aspirin effect might be influenced by bodyweight, with decreased efficacy in heavier individuals. We investigated the influence of bodyweight on aspirin pharmacodynamics in two independent datasets of patients taking non-enteric… read more here.
Keywords: response; increased bodyweight; aspirin; adjusted value ... See more keywords
Screening Large Population Health Databases for Potential COVID-19 Therapeutics: A Pharmacopeia-Wide Association Study (PWAS) of Commonly Prescribed Medications
Sign Up to like & getrecommendations! Published in 2022 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac156
Abstract: Abstract Background For both the current and future pandemics, there is a need for high-throughput drug screening methods to identify existing drugs with potential preventative and/or therapeutic activity. Epidemiologic studies could complement lab-focused efforts to… read more here.
Keywords: pharmacopeia wide; drug; weighted standard; value ... See more keywords
The Role of Gut Microbiota in Modulating Efficacy and Adverse Effects of CAR T-Cell Therapy in the Pediatric Population
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-211415
Abstract: Introduction The gut microbiome, the trillions of bacteria residing within the human gastrointestinal tract, appear to be critical for modulating cancer immunotherapy efficacy. In fact, adult patients who respond to chimeric antigen receptor T-cell (CAR-T)… read more here.
Keywords: adjusted value; therapy; adverse effects; car ... See more keywords
Transcriptomic signatures responding to PKM2 activator TEPP-46 in the hyperglycemic human renal proximal epithelial tubular cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.965379
Abstract: Pyruvate kinase M2 (PKM2), as the terminal and last rate-limiting enzyme of the glycolytic pathway, is an ideal enzyme for regulating metabolic phenotype. PKM2 tetramer activation has shown a protective role against diabetic kidney disease… read more here.
Keywords: renal proximal; human renal; pkm2; value ... See more keywords