Polysaccharide from Phellinus Igniarius activates TLR4-mediated signaling pathways in macrophages and shows immune adjuvant activity in mice.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.11.066
Abstract: Polysaccharide from Phellinus igniarius (PPI) is known for its immune-regulating effect with low toxicity. Toll like receptor 4 (TLR4) is important in both innate and adaptive immune responses and considered to be a promising target… read more here.
Keywords: phellinus igniarius; immune adjuvant; polysaccharide phellinus; adjuvant activity ... See more keywords
Structural Fine-Tuning of Desmuramylpeptide NOD2 Agonists Defines Their In Vivo Adjuvant Activity
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c00644
Abstract: We report on the design, synthesis, and biological evaluation of a series of nucleotide-binding oligomerization-domain-containing protein 2 (NOD2) desmuramylpeptide agonists with improved in vitro and in vivo adjuvant properties. We identified two promising compounds: 68,… read more here.
Keywords: fine tuning; vivo adjuvant; adjuvant activity; structural fine ... See more keywords
Brominated Carbazole with Antibiotic Adjuvant Activity Displays Pleiotropic Effects in MRSA's Transcriptome.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00168
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) is a major threat to human health, as the US mortality rate outweighs those from HIV, tuberculosis, and viral hepatitis combined. In the wake of the COVID-19 pandemic, antibiotic-resistant bacterial infections… read more here.
Keywords: adjuvant activity; adjuvant; brominated carbazole; antibiotic adjuvant ... See more keywords
Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy
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DOI: 10.1038/s41598-020-65422-1
Abstract: Toll-like receptors (TLRs) play crucial roles in host immune defenses. Recently, TLR-mediated autophagy is reported to promote immune responses via increasing antigen processing and presentation in antigen presenting cells. The present study examined whether the… read more here.
Keywords: ccl; adjuvant activity; antigen specific; vaccine adjuvant ... See more keywords
Genetic Dissection of Antibiotic Adjuvant Activity
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DOI: 10.1128/mbio.03084-21
Abstract: One strategy to confront the antibiotic resistance crisis is through the development of adjuvant compounds that increase the efficacy of established drugs. A key step in the development of a natural product adjuvant as a… read more here.
Keywords: development; strategy; resistance; activity ... See more keywords
Adjuvant activity of tubeimosides by mediating the local immune microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1108244
Abstract: Rhizoma Bolbostemmatis, the dry tuber of Bolbostemma paniculatum, has being used for the treatment of acute mastitis and tumors in traditional Chinese medicine. In this study, tubeimoside (TBM) I, II, and III from this drug… read more here.
Keywords: local immune; immune microenvironment; activity; adjuvant activity ... See more keywords
Lipidation of NOD2 Agonists with Adamantane and Stearoyl Moieties Differentially Regulates Their In Vivo Adjuvant Activity
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14122755
Abstract: NOD2 is an innate immune receptor that constitutes an important target for the development of small molecule immunopotentiators with great potential to be used as vaccine adjuvants. We report here the results of an in… read more here.
Keywords: nod2 agonists; immune response; adjuvant activity; lipidation nod2 ... See more keywords