Levetiracetam mitigates lipopolysaccharide‐induced JAK2/STAT3 and TLR4/MAPK signaling pathways activation in a rat model of adjuvant‐ induced arthritis
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.02.041
Abstract: &NA; Levetiracetam (LEV), a novel anti‐epileptic drug that has been demonstrated with an anti‐inflammatory effect, but the exact mechanisms of its action remain to be fully defined. The present study aimed to evaluate the possible… read more here.
Keywords: induced arthritis; jak2 stat3; adjuvant induced; tlr4 ... See more keywords
PSTPIP2 attenuates joint damage and suppresses inflammation in adjuvant-induced arthritis.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172558
Abstract: Proline-serine-threonine-phosphatase-interacting protein 2 (PSTPIP2) is related to inflammation. In this study, we investigated the function of PSTPIP2 in adjuvant-induced arthritis (AIA) by using adeno-associated virus (AAV) to overexpress PSTPIP2 in rat. AIA rats were developed… read more here.
Keywords: induced arthritis; pstpip2; inflammation; adjuvant induced ... See more keywords
Ketoprofen and MicroRNA‐124 Co‐loaded poly (lactic‐co‐glycolic acid) microspheres inhibit progression of Adjuvant‐induced arthritis in rats
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.09.063
Abstract: ABSTRACT Ketoprofen, a non‐steroid anti‐inflammatory drug, is widely used for relieving the pain and swelling caused by rheumatoid arthritis. However, ketoprofen can’t suppress disease progression effectively. In this study, in an effort to improve the… read more here.
Keywords: induced arthritis; 124 loaded; arthritis rats; adjuvant induced ... See more keywords
Dehydroevodiamine Suppresses Inflammatory Responses in Adjuvant-Induced Arthritis Rats and Human Fibroblast-Like Synoviocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1999554
Abstract: Dehydroevodiamine (DHE) is an effective natural active substance extracted from Euodiae Fructus, which is a widely used herbal drug in traditional Chinese medicine. The focus of this study was to test the possibility of using… read more here.
Keywords: induced arthritis; human fibroblast; aia rats; adjuvant induced ... See more keywords
Adjuvant‐induced arthritis affects testes and ventral prostate of Wistar rats
Sign Up to like & getrecommendations! Published in 2019 at "Andrology"
DOI: 10.1111/andr.12693
Abstract: Rheumatoid arthritis (RA) may reduce the testosterone production, thereby leading to testicular dysfunction and subfertility. read more here.
Keywords: induced arthritis; affects testes; testes ventral; arthritis affects ... See more keywords
Macrophage and dendritic cell subset composition can distinguish endotypes in adjuvant-induced asthma mouse models
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0250533
Abstract: Asthma is a heterogeneous disease with neutrophilic and eosinophilic asthma as the main endotypes that are distinguished according to the cells recruited to the airways and the related pathology. Eosinophilic asthma is the treatment-responsive endotype,… read more here.
Keywords: mouse models; eosinophilic asthma; adjuvant induced; macrophage dendritic ... See more keywords
Effects of Multimodal Therapy, Blinding, and Multi-laboratory Protocol Conduct on the Robustness of the Rat Model of Adjuvant Induced Arthritis
Sign Up to like & getrecommendations! Published in 2023 at "In Vivo"
DOI: 10.21873/invivo.13060
Abstract: Abstract Background/Aim: The aim of this study was to investigate the effects of multimodal therapy comprising buprenorphine (BUP) and indomethacin (IND) on key translational parameters in the rat adjuvant induced arthritis (AIA) model. Furthermore, we… read more here.
Keywords: induced arthritis; multi laboratory; adjuvant induced; multimodal therapy ... See more keywords
Effects of Transdermal Fentanyl Treatment on Acute Pain and Inflammation in Rats with Adjuvant-induced Monoarthritis.
Sign Up to like & getrecommendations! Published in 2022 at "Comparative medicine"
DOI: 10.30802/aalas-cm-21-000066
Abstract: Eliminating unnecessary pain is an important requirement of performing animal experimentation, including reducing and controlling pain of animals used in pain research. The goal of this study was to refine an adjuvant-induced monoarthritis model in… read more here.
Keywords: adjuvant induced; induced monoarthritis; pain; transdermal fentanyl ... See more keywords
Celastrol Efficacy by Oral Administration in the Adjuvant-Induced Arthritis Model
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2020.00455
Abstract: Background: We previously demonstrated that celastrol has significant anti-inflammatory and bone protective effects when administered via the intraperitoneal route. For further preclinical evaluation, an effective oral administration of celastrol is crucial. Here we aimed to… read more here.
Keywords: induced arthritis; celastrol; adjuvant induced; day ... See more keywords
Chemical Composition of Pterospermum heterophyllum Root and its Anti-Arthritis Effect on Adjuvant-Induced Arthritis in Rats via Modulation of Inflammatory Responses
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.584849
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease without effective and beneficial drugs. Many traditional folk medicines have been proven to be effective in treating RA. Among these, the root of Pterospermum heterophyllum Hance… read more here.
Keywords: effect; adjuvant induced; heterophyllum; arthritis ... See more keywords
Sp1 S-Sulfhydration Induced by Hydrogen Sulfide Inhibits Inflammation via HDAC6/MyD88/NF-κB Signaling Pathway in Adjuvant-Induced Arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11040732
Abstract: Histone deacetylase 6 (HDAC6) acts as a regulator of the nuclear factor kappa-B (NF-κB) signaling pathway by deacetylating the non-histone protein myeloid differentiation primary response 88 (MyD88) at lysine residues, which is an adapter protein… read more here.
Keywords: induced arthritis; adjuvant induced; signaling pathway; hdac6 ... See more keywords