Effect of Chiral Purity on Adjuvanticity of Archaeol-Based Glycolipids.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00072
Abstract: Archaeosomes composed of sulfated lactosyl archaeol (SLA) glycolipids from stereoisomerically pure archaeol (1) are vaccine adjuvants that can boost immunogenicity and vaccine efficacy in preclinical models. Herein, we report a new synthesis of 2,3-bis((3,7,11,15-tetramethylhexadecyl)oxy) propan-1-ol… read more here.
Keywords: effect; adjuvanticity; stereochemistry; effect chiral ... See more keywords
Immunogenic stress and death of cancer cells: Contribution of antigenicity vs adjuvanticity to immunosurveillance
Sign Up to like & getrecommendations! Published in 2017 at "Immunological Reviews"
DOI: 10.1111/imr.12582
Abstract: Cancer cells are subjected to constant selection by the immune system, meaning that tumors that become clinically manifest have managed to subvert or hide from immunosurveillance. Immune control can be facilitated by induction of autophagy,… read more here.
Keywords: adjuvanticity; cancer cells; cancer; immunosurveillance ... See more keywords
Critical micelle concentration and particle size determine adjuvanticity of cyclic lipopeptides
Sign Up to like & getrecommendations! Published in 2018 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12698
Abstract: Cyclic lipopeptides such as surfactin and polymyxin have potent mucosal adjuvant properties. Cyclic lipopeptides are tensioactive compounds, but the relationship between adjuvanticity and surface activity is unknown. Here, we show that the critical micelle concentration… read more here.
Keywords: critical micelle; size; cyclic lipopeptides; concentration ... See more keywords
Machine Learning-Assisted Screening of Herbal Medicine Extracts as Vaccine Adjuvants
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.847616
Abstract: Adjuvants are important vaccine components, composed of a variety of chemical and biological materials that enhance the vaccine antigen-specific immune responses by stimulating the innate immune cells in both direct and indirect manners to produce… read more here.
Keywords: learning assisted; adjuvanticity; machine learning; assisted screening ... See more keywords
The Integrity of α-β-α Sandwich Conformation Is Essential for a Novel Adjuvant TFPR1 to Maintain Its Adjuvanticity
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DOI: 10.3390/biom9120869
Abstract: TFPR1 is a novel peptide vaccine adjuvant we recently discovered. To define the structural basis and optimize its application as an adjuvant, we designed three different truncated fragments that have removed dominant B epitopes on… read more here.
Keywords: integrity sandwich; tfpr1 maintain; tfpr1; conformation essential ... See more keywords