Preclinical optimization of gp120 entry-antagonists as anti-HIV-1 agents with improved cytotoxicity and ADME properties through rational design, synthesis, and antiviral evaluation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b02149
Abstract: We previously reported a milestone in the optimization of NBD-11021, an HIV-1 gp120 antagonist, by developing a new and novel analog, NBD-14189 (Ref1), which showed antiviral activity against HIV-1HXB2, with an IC50 of 89 nM.… read more here.
Keywords: preclinical optimization; optimization; gp120 entry; adme ... See more keywords
A novel adaptive ensemble classification framework for ADME prediction
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra01206g
Abstract: It has now become clear that in silico prediction of ADME (absorption, distribution, metabolism, and elimination) characteristics is an important component of the drug discovery process. Therefore, there has been considerable interest in the development… read more here.
Keywords: ensemble classification; adme prediction; adme; novel adaptive ... See more keywords
Factors Influencing ADME properties of therapeutic antisense oligonucleotides: physicochemical characteristics and beyond.
Sign Up to like & getrecommendations! Published in 2023 at "Current drug metabolism"
DOI: 10.2174/1389200224666230418092626
Abstract: Therapeutic antisense oligonucleotides (ASOs) represent a diverse array of chemically modified singlestranded deoxyribonucleotides that work complementarily to affect their mRNA targets. They vastly differ from conventional small molecules. These newly developed therapeutic ASOs possess unique… read more here.
Keywords: factors influencing; adme; antisense oligonucleotides; adme properties ... See more keywords
Novel 7-Chloro-4-aminoquinoline-benzimidazole Hybrids as Inhibitors of Cancer Cells Growth: Synthesis, Antiproliferative Activity, in Silico ADME Predictions, and Docking
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020540
Abstract: In this study, new 7-chloro-4-aminoquinoline-benzimidazole compounds were synthesized and characterized by NMR, MS, and elemental analysis. These novel hybrids differ in the type of linker and in the substituent on the benzimidazole moiety. Their antiproliferative… read more here.
Keywords: chloro aminoquinoline; aminoquinoline benzimidazole; adme; activity ... See more keywords