Key Physicochemical Characteristics Influencing ADME Properties of Therapeutic Proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-7709-9_6
Abstract: Therapeutic proteins are a rapidly growing class of drugs in clinical settings. The pharmacokinetics (PK) of therapeutic proteins relies on their absorption, distribution, metabolism, and excretion (ADME) properties. Moreover, the ADME properties of therapeutic proteins… read more here.
Keywords: therapeutic proteins; key physicochemical; adme properties; properties therapeutic ... See more keywords
Factors Influencing ADME properties of therapeutic antisense oligonucleotides: physicochemical characteristics and beyond.
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DOI: 10.2174/1389200224666230418092626
Abstract: Therapeutic antisense oligonucleotides (ASOs) represent a diverse array of chemically modified singlestranded deoxyribonucleotides that work complementarily to affect their mRNA targets. They vastly differ from conventional small molecules. These newly developed therapeutic ASOs possess unique… read more here.
Keywords: factors influencing; adme; antisense oligonucleotides; adme properties ... See more keywords
Comparison of Pinoresinol and its Diglucoside on their ADME Properties and Vasorelaxant Effects on Phenylephrine-Induced Model
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DOI: 10.3389/fphar.2021.695530
Abstract: Pinoresinol (PINL) and pinoresinol diglucoside (PDG), two natural lignans found in Eucommia ulmoides Oliv. (Duzhong), have several pharmacological activities. However, there is no report available on their absorption, distribution, metabolism, and elimination (ADME) properties. Given… read more here.
Keywords: phenylephrine induced; vasorelaxant effects; pinl; adme properties ... See more keywords
Study of Lipophilicity and ADME Properties of 1,9-Diazaphenothiazines with Anticancer Action
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DOI: 10.3390/ijms24086970
Abstract: Lipophilicity is one of the key properties of a potential drug that determines the solubility, the ability to penetrate through cell barriers, and transport to the molecular target. It affects pharmacokinetic processes such as adsorption,… read more here.
Keywords: lipophilicity; diazaphenothiazines anticancer; properties diazaphenothiazines; adme properties ... See more keywords