Getting a molecule into the clinic: Nonclinical testing and starting dose considerations
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DOI: 10.1016/j.yrtph.2017.07.027
Abstract: &NA; Examination of content of 35 Investigator Brochures (IBs) for small molecules (including some for oncology) used to support First‐In‐Human studies over a 2 year period (2014–2016) showed that a mean of 37 nonclinical studies… read more here.
Keywords: molecule; starting dose; pharmacology; toxicology testing ... See more keywords