Predicting the Pharmacokinetics of Orally Administered Drugs across BCS Classes 1-4 by Virtual Bioequivalence Model.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00688
Abstract: To evaluate the influence of solubility and permeability on the pharmacokinetic prediction performance of orally administered drugs using avirtual bioequivalence (VBE) model, a total of 23 orally administered drugs covering Biopharmaceutics Classification System (BCS) classes… read more here.
Keywords: orally administered; administered drugs; error; bioequivalence ... See more keywords
Interaction of drugs with gut microbiota modulators.
Sign Up to like & getrecommendations! Published in 2023 at "Drug metabolism reviews"
DOI: 10.1080/03602532.2023.2197178
Abstract: Orally administered drugs undergo four stages of absorption, distribution, metabolism, and excretion in the body. However, before being absorbed into the body, orally administered drugs contact with gut microbiota, which catalyze their metabolic reactions such… read more here.
Keywords: microbiota modulators; orally administered; microbiota; gut microbiota ... See more keywords
Current Trends in Simultaneous Determination of Co-Administered Drugs
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DOI: 10.3390/separations7020029
Abstract: Recently, high demand of high-throughput analyses with high sensitivity and selectivity to molecules and drugs in different classes with different physical-chemical properties—and a reduction in analysis time—is a principal milestone for novel methodologies that researchers… read more here.
Keywords: simultaneous determination; current trends; administered drugs; trends simultaneous ... See more keywords