Predicting the Pharmacokinetics of Orally Administered Drugs across BCS Classes 1-4 by Virtual Bioequivalence Model.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00688
Abstract: To evaluate the influence of solubility and permeability on the pharmacokinetic prediction performance of orally administered drugs using avirtual bioequivalence (VBE) model, a total of 23 orally administered drugs covering Biopharmaceutics Classification System (BCS) classes… read more here.
Keywords: orally administered; administered drugs; error; bioequivalence ... See more keywords
Ecofriendly spectrophotometric methods for simultaneous determination of remdesivir and moxifloxacin hydrochloride as co administered drugs in corona virus treatment
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-024-83049-4
Abstract: Remdesivir and moxifloxacin hydrochloride are among the most frequently co-administered drugs used for COVID-19 treatment. The current work aims to evaluate green spectrophotometric methodologies for estimating remdesivir and moxifloxacin hydrochloride in different matrices for the… read more here.
Keywords: administered drugs; moxifloxacin hydrochloride; remdesivir; remdesivir moxifloxacin ... See more keywords
Interaction of drugs with gut microbiota modulators.
Sign Up to like & getrecommendations! Published in 2023 at "Drug metabolism reviews"
DOI: 10.1080/03602532.2023.2197178
Abstract: Orally administered drugs undergo four stages of absorption, distribution, metabolism, and excretion in the body. However, before being absorbed into the body, orally administered drugs contact with gut microbiota, which catalyze their metabolic reactions such… read more here.
Keywords: microbiota modulators; orally administered; microbiota; gut microbiota ... See more keywords
General anesthesia and systemic hyperosmolality modulate lumbar intrathecal drug distribution in female rats.
Sign Up to like & getrecommendations! Published in 2025 at "Anesthesiology"
DOI: 10.1097/aln.0000000000005794
Abstract: Background: Spinal administration of drugs largely bypasses the blood–brain barrier that reduces the central nervous system (CNS) availability of most systemically administered drugs. Current methods for lumbar intrathecal drug delivery fail to deliver therapeutic concentrations… read more here.
Keywords: administered drugs; distribution; drug; ketamine dexmedetomidine ... See more keywords
Editorial for the Special Issue: Pharmacokinetics of Orally Administered Drugs, 2nd Edition
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DOI: 10.3390/pharmaceutics16081078
Abstract: Oral administration of medicines has been the most common route for drug delivery as it is cost-effective and is convenient for patients [...]. read more here.
Keywords: administered drugs; issue pharmacokinetics; pharmacokinetics orally; special issue ... See more keywords
Current Trends in Simultaneous Determination of Co-Administered Drugs
Sign Up to like & getrecommendations! Published in 2020 at "Separations"
DOI: 10.3390/separations7020029
Abstract: Recently, high demand of high-throughput analyses with high sensitivity and selectivity to molecules and drugs in different classes with different physical-chemical properties—and a reduction in analysis time—is a principal milestone for novel methodologies that researchers… read more here.
Keywords: simultaneous determination; current trends; administered drugs; trends simultaneous ... See more keywords