Payload-binding Fab fragments increase the therapeutic index of MMAE antibody-drug conjugates.
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DOI: 10.1158/1535-7163.mct-22-0440
Abstract: Monomethyl auristatin E (MMAE) is a potent tubulin inhibitor that is used as the payload for four FDA-approved antibody drug conjugates (ADCs). Deconjugated MMAE readily diffuses into untargeted cells resulting in off-target toxicity. Here we… read more here.
Keywords: cell; drug conjugates; mmae; administration abc3315 ... See more keywords