Safety implications of concomitant administration of antidepressants and opioid analgesics in surgical patients.
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DOI: 10.1080/14740338.2023.2181333
Abstract: BACKGROUND Commonly prescribed antidepressants (paroxetine, fluoxetine, duloxetine, bupropion) inhibit bioconversion of several prodrug opioid medications to their active metabolite, potentially decreasing analgesic effect. There is a paucity of studies assessing the risk-benefit of concomitant administration… read more here.
Keywords: administration antidepressants; safety; concomitant administration; risk ... See more keywords