Next Generation of Adoptive T Cell Therapy Using CRISPR/Cas9 Technology: Universal or Boosted?
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0290-4_22
Abstract: Adoptive T cell therapy (ACT) using either chimeric antigen receptor (CAR)- or T cell receptor (TCR)-engineered lymphocytes has emerged as a promising strategy to treat cancer. However, this therapy is still facing enormous challenges such… read more here.
Keywords: cell therapy; adoptive cell; crispr cas9; next generation ... See more keywords
Immune biomarkers for predicting response to adoptive cell transfer as cancer treatment
Sign Up to like & getrecommendations! Published in 2018 at "Immunogenetics"
DOI: 10.1007/s00251-018-1083-1
Abstract: Adoptive cell transfer (ACT) is a form of personalised immunotherapy which has shown promising results in metastasised cancer. For this treatment, autologous T lymphocytes are selected and stimulated in vitro before re-administration in large numbers.… read more here.
Keywords: response; adoptive cell; treatment; cell transfer ... See more keywords
Brief in vitro IL-12 conditioning of CD8 + T Cells for anticancer adoptive T cell therapy
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-021-02887-7
Abstract: Cancer immunotherapy represents a potential treatment approach through non-specific and specific enhancement of the immune responses. Adoptive cell therapy (ACT) is a potential modality of immunotherapy that depends on harvesting T cells from the tumor-bearing… read more here.
Keywords: conditioning; cell therapy; cd8 cells; adoptive cell ... See more keywords
Manipulating the tumor microenvironment by adoptive cell transfer of CAR T-cells
Sign Up to like & getrecommendations! Published in 2018 at "Mammalian Genome"
DOI: 10.1007/s00335-018-9756-5
Abstract: T-cells expressing synthetic chimeric antigen receptors (CARs) have revolutionized immuno-oncology and highlighted the use of adoptive cell transfer, for the treatment of cancer. The phenomenal clinical success obtained in the treatment of hematological malignancies with… read more here.
Keywords: adoptive cell; cell transfer; car cells; car ... See more keywords
Prospective randomized comparative study on rivaroxaban and LMWH for prophylaxis of post-apheresis thrombosis in adoptive T cell immunotherapy cancer patients
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-019-01844-7
Abstract: Autologous adoptive T cell immunotherapy has been recognized as an effective treatment for cancer patients. The initial qualified lymphocytes is the core element determining the immunotherapeutic outcomes clinically. Cell separator based apheresis procedure is an… read more here.
Keywords: lmwh; cancer patients; adoptive cell; apheresis ... See more keywords
Genome-Editing Technologies in Adoptive T Cell Immunotherapy for Cancer
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DOI: 10.1007/s11899-017-0417-7
Abstract: Purpose of ReviewIn this review, we discuss the most recent developments in gene-editing technology and discuss their application to adoptive T cell immunotherapy.Recent FindingsEngineered T cell therapies targeting cancer antigens have demonstrated significant efficacy in… read more here.
Keywords: cell immunotherapy; adoptive cell; editing technologies; cancer ... See more keywords
Generation of glucocorticoid-resistant SARS-CoV-2 T cells for adoptive cell therapy
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.109432
Abstract: Adoptive cell therapy with viral-specific T cells has been successfully used to treat life-threatening viral infections, supporting the application of this approach against COVID-19. We expand SARS-CoV-2 T-cells from the peripheral blood of COVID-19-recovered donors… read more here.
Keywords: cov cells; sars cov; adoptive cell; cell therapy ... See more keywords
Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.02.024
Abstract: Adoptive T cell therapy (ACT) produces durable responses in some cancer patients; however, most tumors are refractory to ACT and the molecular mechanisms underlying resistance are unclear. Using two independent approaches, we identified tumor glycolysis as… read more here.
Keywords: glycolysis; tumor glycolysis; adoptive cell; resistance ... See more keywords
Pharmacological and genetic strategies for targeting adenosine to enhance adoptive T cell therapy of cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2020.07.002
Abstract: Adoptive cellular therapy involves the ex vivo expansion of immune cells, conventionally T cells, before reinfusion back to the patient. Variations in adoptive cellular therapy include transduction of a patient's T cells with either a… read more here.
Keywords: adoptive cellular; adoptive cell; therapy; enhance adoptive ... See more keywords
KRAS Inhibitors- yes but what next? Direct targeting of KRAS- vaccines, adoptive T cell therapy and beyond.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2021.102309
Abstract: Kirsten rat sarcoma viral oncogene homolog (KRAS) is a proto-oncogene of the RAS-MAPK pathway. KRAS mutations are present in a variety of malignancies including lung, colorectal, and pancreatic cancer. Until the recent approval of sotorasib,… read more here.
Keywords: kras inhibitors; cell therapy; adoptive cell; vaccines adoptive ... See more keywords
Enhancing Adoptive Cell Therapy by T Cell Loading of SHP2 Inhibitor Nanocrystals before Infusion.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c03311
Abstract: Whereas adoptive T cell therapy has been extensively studied for cancer treatment, the response is still limited primarily due to immune dysfunction related to poor cell engraftment, tumor infiltration and engagement, and lack of a… read more here.
Keywords: shp099; cell; cell therapy; adoptive cell ... See more keywords