Killers at the crossroads: The use of innate immune cells in adoptive cellular therapy of cancer
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.19-0423
Abstract: Abstract Adoptive cell therapy (ACT) is an approach to cancer treatment that involves the use of antitumor immune cells to target residual disease in patients after completion of chemo/radiotherapy. ACT has several advantages compared with… read more here.
Keywords: therapy; adoptive cellular; cells adoptive; cancer ... See more keywords
Pharmacological and genetic strategies for targeting adenosine to enhance adoptive T cell therapy of cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2020.07.002
Abstract: Adoptive cellular therapy involves the ex vivo expansion of immune cells, conventionally T cells, before reinfusion back to the patient. Variations in adoptive cellular therapy include transduction of a patient's T cells with either a… read more here.
Keywords: adoptive cellular; adoptive cell; therapy; enhance adoptive ... See more keywords
Evaluation of an Adoptive Cellular Therapy-Based Vaccine in a Transgenic Mouse Model of α-synucleinopathy
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00539
Abstract: Aggregated α-synuclein, a major constituent of Lewy bodies plays a crucial role in the pathogenesis of α-synucleinopathies (SPs) such as Parkinson’s disease (PD). PD is affected by the innate and adaptive arms of the immune… read more here.
Keywords: evaluation adoptive; therapy based; cellular therapy; model ... See more keywords
The promise of adoptive cellular immunotherapies in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Oncoimmunology"
DOI: 10.1080/2162402x.2019.1673129
Abstract: ABSTRACT Hepatocellular Carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. Current systemic therapies result only in modest benefits and new therapeutic options are critically needed. Some patients show promising clinical responses… read more here.
Keywords: hepatocellular carcinoma; immunotherapies hepatocellular; carcinoma; adoptive cellular ... See more keywords
Massive clonal expansion of medulloblastoma-specific T cells during adoptive cellular therapy
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aav9879
Abstract: Extensive clonal T cell expansion is associated with response to immunotherapy. In both human and murine systems, we have developed an adoptive cellular therapy platform against medulloblastoma and glioblastoma that uses dendritic cells pulsed with… read more here.
Keywords: expansion; adoptive cellular; medulloblastoma; cellular therapy ... See more keywords
Abstract 662: IMA_Detect: Mass spectrometry guided development and clinical application of a companion diagnostic for adoptive cellular therapy against tumor associated HLA peptides
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-662
Abstract: Adoptive cellular therapy (ACT) has dramatically changed the landscape of cancer immunotherapy. ACTolog® and ACTengine® are actively personalized ACT approaches employing T-cell receptor products based on a warehouse of human leucocyte antigen (HLA)-bound peptide targets.… read more here.
Keywords: ima detect; adoptive cellular; therapy; cellular therapy ... See more keywords
Abstract 1194: Adoptive cellular therapy overcomes tumor-induced dysregulation of myelopoiesis
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-1194
Abstract: INTRODUCTION: Hematopoietic stem and progenitor cell (HSPC) transfer during adoptive T cell immunotherapy (ACT) prolongs median survival and generates 30% long-term cures for malignant brain tumors. We recently demonstrated during ACT that intratumoral HSPCs differentiate… read more here.
Keywords: adoptive cellular; naive hspcs; cell; hspc ... See more keywords
Abstract 2327: Same day transduction andin vivoexpansion of chimeric antigen receptors and synthetic driver constructs for adoptive cellular therapy
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-2327
Abstract: Adoptive cellular therapy (ACT) using ex vivo expanded chimeric antigen receptor (CAR) modified T cells to target cancer cells expressing CD19 has been very successful in the treatment of hematologic malignancies and the clinical application… read more here.
Keywords: cellular therapy; chimeric antigen; car; adoptive cellular ... See more keywords
Potential biomarkers: Identifying powerful tumor specific T cells in adoptive cellular therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1003626
Abstract: Tumor-specific T cells (TSTs) are essential components for the success of personalized tumor-infiltrating lymphocyte (TIL)-based adoptive cellular therapy (ACT). Therefore, the selection of a common biomarker for screening TSTs in different tumor types, followed by… read more here.
Keywords: tumor specific; specific cells; cellular therapy; tumor ... See more keywords