Determination of the Fate and Function of Innate Lymphoid Cells Following Adoptive Transfer of Innate Lymphoid Cell Precursors.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7896-0_10
Abstract: Innate lymphoid cells are a heterogeneous family of tissue-resident and circulating lymphocytes that play an important role in host immunity. Recent studies have profiled the developmental pathways of mature ILCs and have identified ILC progenitors… read more here.
Keywords: innate; innate lymphoid; lymphoid cells; adoptive transfer ... See more keywords
Expansion and Adoptive Transfer of Human Vδ2+ T Cells to Assess Antitumor Effects In Vivo.
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DOI: 10.1007/978-1-4939-8885-3_4
Abstract: Recent clinical trials have yielded promising results suggesting that γδ T cell62-based immunotherapies can be effective against hematological malignancies. Human T cells expressing Vγ9Vδ2+ receptors are particularly attractive candidates for this application, since they can… read more here.
Keywords: expansion adoptive; cells assess; adoptive transfer; transfer human ... See more keywords
Adoptive transfer of tumor-specific Th9 cells eradicates heterogeneous antigen-expressing tumor cells.
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DOI: 10.1016/j.ccell.2021.10.013
Abstract: In this issue of Cancer Cell, Xue et al. demonstrate that adoptive transfer of tumor-specific Th9 cells can eradicate established tumors containing antigen-loss-variant cells (ALVs) through both direct killing and bystander effects mediated by intratumoral accumulation… read more here.
Keywords: th9 cells; tumor specific; adoptive transfer; transfer tumor ... See more keywords
Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8+ T cells eradicates peritoneal metastases in mouse models
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DOI: 10.1080/2162402x.2022.2147317
Abstract: ABSTRACT Previous studies have shown that local delivery of tumor antigen-specific CD8+ T lymphocytes engineered to transiently express single-chain IL-12 mRNA is highly efficacious. Peritoneal dissemination of cancer is a frequent and often fatal patient… read more here.
Keywords: specific cd8; tumor; intracavitary adoptive; adoptive transfer ... See more keywords
Restoring antiviral immunity with adoptive transfer of ex-vivo generated T cells
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Hematology"
DOI: 10.1097/moh.0000000000000461
Abstract: Purpose of review Latent viruses such as cytomegalovirus (CMV), Epstein–Barr virus (EBV) and adenovirus (ADV) often reactivate in immunocompromised patients, contributing to poor clinical outcomes. A rapid reconstitution of antiviral responses via adoptive transfer of… read more here.
Keywords: transfer vivo; antiviral immunity; transfer; adoptive transfer ... See more keywords
Impact of Prior Treatment on the Efficacy of Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma
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DOI: 10.1158/1078-0432.ccr-21-1171
Abstract: Purpose: Adoptive cell transfer (ACT) of autologous tumor-infiltrating lymphocytes (TIL) can mediate durable responses in patients with metastatic melanoma. This retrospective analysis provides long-term follow-up and describes the effect of prior therapy on outcomes after… read more here.
Keywords: treatment; metastatic melanoma; patients metastatic; tumor ... See more keywords
Adoptive Transfer of HPV-Targeted T Cells Is Active in Epithelial Cancer.
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DOI: 10.1158/2159-8290.cd-rw2019-132
Abstract: Adaptive transfer of engineered T cells promoted tumor regression and objective responses in epithelial cancer. read more here.
Keywords: transfer hpv; epithelial cancer; cancer; hpv targeted ... See more keywords
Adoptive transfer of tumor-infiltrating lymphocytes in melanoma: a viable treatment option
Sign Up to like & getrecommendations! Published in 2018 at "Journal for Immunotherapy of Cancer"
DOI: 10.1186/s40425-018-0391-1
Abstract: The treatment of metastatic melanoma patients with autologous tumor-infiltrating lymphocytes (TIL) shows robust, reproducible, clinical responses in clinical trials executed in several specialized centers over the world. Even in the era of targeted therapy and… read more here.
Keywords: infiltrating lymphocytes; til therapy; treatment; tumor infiltrating ... See more keywords
Adoptive transfer of dendritic cells expressing CD11c reduces the immunological response associated with experimental colitis in BALB/c mice
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DOI: 10.1371/journal.pone.0196994
Abstract: Introduction In addition to conventional therapies, several new strategies have been proposed for modulating autoimmune diseases, including the adoptive transfer of immunological cells. In this context, dendritic cells (DCs) appear to be one of the… read more here.
Keywords: cd11c; colitis; dendritic cells; mice ... See more keywords
Leveraging Natural Killer Cell Innate Immunity against Hematologic Malignancies: From Stem Cell Transplant to Adoptive Transfer and Beyond
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010204
Abstract: Numerous recent advancements in T-cell based immunotherapies have revolutionized the treatment of hematologic malignancies. In the race towards the first approved allogeneic cellular therapy product, there is growing interest in utilizing natural killer (NK) cells… read more here.
Keywords: cell; stem cell; hematologic malignancies; natural killer ... See more keywords