Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-019-12901-3
Abstract: Interleukin-2 (IL-2) is a component of most protocols of adoptive cell transfer (ACT) therapy for cancer, but is limited by short exposure and high toxicities. NKTR-214 is a kinetically-engineered IL-2 receptor βγ (IL-2Rβγ)-biased agonist consisting… read more here.
Keywords: nktr 214; transferred cells; act; adoptively transferred ... See more keywords
Immunostimulatory functions of adoptively transferred MDSCs in experimental blunt chest trauma
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44419-5
Abstract: Myeloid-derived suppressor cells (MDSCs) expand during inflammation and exhibit immunomodulatory functions on innate and adaptive immunity. However, their impact on trauma-induced immune responses, characterized by an early pro-inflammatory phase and dysregulated adaptive immunity involving lymphocyte… read more here.
Keywords: chest trauma; experimental blunt; transferred mdscs; trauma ... See more keywords
Trial Watch: Adoptively transferred cells for anticancer immunotherapy
Sign Up to like & getrecommendations! Published in 2017 at "OncoImmunology"
DOI: 10.1080/2162402x.2017.1363139
Abstract: ABSTRACT Immunotherapies aimed at strengthening immune effector responses against malignant cells are growing at exponential rates. Alongside, the impressive benefits obtained by patients with advanced melanoma who received adoptively transferred tumor-infiltrating lymphocytes (TILs) have encouraged… read more here.
Keywords: trial watch; act; watch adoptively; adoptively transferred ... See more keywords
TIPE2 deletion improves the therapeutic potential of adoptively transferred NK cells
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-006002
Abstract: Background To enhance the efficacy of adoptive NK cell therapy against solid tumors, NK cells must be modified to resist exhaustion in the tumor microenvironment (TME). However, the molecular checkpoint underlying NK cell exhaustion in… read more here.
Keywords: cell; exhaustion; tme; deletion ... See more keywords
Tracking the progeny of adoptively transferred virus-specific T cells in patients posttransplant using TCR sequencing
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2022007270
Abstract: Key Points • In vivo expansion of infused multiantigen-specific T-cell products in response to antigen encounter.• In vivo persistence of infused multiantigen-specific T-cell products in absence of viral reactivation. read more here.
Keywords: transferred virus; tracking progeny; specific cells; virus specific ... See more keywords