Mitochondrial ADP/ATP Carrier in Dodecylphosphocholine Binds Cardiolipins with Non-native Affinity
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2017.09.019
Abstract: Biophysical investigation of membrane proteins generally requires their extraction from native sources using detergents, a step that can lead, possibly irreversibly, to protein denaturation. The propensity of dodecylphosphocholine (DPC), a detergent widely utilized in NMR… read more here.
Keywords: atp carrier; mitochondrial adp; dpc; adp atp ... See more keywords
The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2018.11.025
Abstract: Summary Mitochondrial ADP/ATP carriers transport ADP into the mitochondrial matrix for ATP synthesis, and ATP out to fuel the cell, by cycling between cytoplasmic-open and matrix-open states. The structure of the cytoplasmic-open state is known,… read more here.
Keywords: mitochondrial adp; adp atp; carrier; mechanism ... See more keywords
Molecular dynamics simulations on apo ADP/ATP carrier shed new lights on the featured motif of the mitochondrial carriers.
Sign Up to like & getrecommendations! Published in 2019 at "Mitochondrion"
DOI: 10.1016/j.mito.2019.05.006
Abstract: The ADP/ATP carrier (AAC) is a transporter responsible for the equal molar exchange of cytosolic ADP and ATP synthesized within mitochondrial matrix across the mitochondrial membrane. Its primary structure consists of three homologous repeats, and… read more here.
Keywords: atp carrier; atp; molecular dynamics; adp atp ... See more keywords
Epoxycyclohexenedione-Type Compounds Make Up a New Class of Inhibitors of the Bovine Mitochondrial ADP/ATP Carrier.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b01119
Abstract: Through the extensive screening of our chemical library, we found epoxycyclohexenedione (ECHD)-type compounds (AMM-59 and -120) as unique inhibitors of the bovine heart mitochondrial ADP/ATP carrier (AAC). This study investigated the mechanism of inhibition of… read more here.
Keywords: aggregation; atp carrier; mitochondrial adp; inhibitors bovine ... See more keywords
Monitoring ADP and ATP in vivo using a fluorescent Ga(iii)-probe complex.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc06311g
Abstract: A naphthol-based sensor (L) was designed and synthesized for the specific recognition of Ga3+ using fluorescence enhancement. An in situ generated L-Ga3+ ensemble detected ADP and ATP more selectively through a fluorescence "switch off" response,… read more here.
Keywords: vivo using; fluorescent iii; monitoring adp; adp atp ... See more keywords
Reversible modification of mitochondrial ADP/ATP translocases by paired Legionella effector proteins
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122872119
Abstract: Significance Mitochondria are organelles of the central metabolism that produce ATP and play fundamental roles in eukaryotic cell function and thereby become targets for pathogenic bacteria to manipulate. We found that the intracellular bacterial pathogen,… read more here.
Keywords: effector proteins; mitochondrial adp; atp translocases; adp atp ... See more keywords
Mitochondrial ADP/ATP Carrier 1 Is Important for the Growth of Toxoplasma Tachyzoites
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00040-23
Abstract: T. gondii has an efficient and flexible energy metabolism system to meet different growth needs. ATP is an energy-carrying molecule and needs to be exchanged between organelles with the assistance of transporters. ABSTRACT Metabolism associated… read more here.
Keywords: growth; atp carrier; energy; adp atp ... See more keywords