The Stories Tryptophans Tell: Exploring Protein Dynamics of Heptosyltransferase I from Escherichia coli.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.6b00850
Abstract: Heptosyltransferase I (HepI) catalyzes the addition of l-glycero-β-d-manno-heptose to Kdo2-Lipid A, as part of the biosynthesis of the core region of lipopolysaccharide (LPS). Gram-negative bacteria with gene knockouts of HepI have reduced virulence and enhanced… read more here.
Keywords: protein dynamics; tryptophans tell; adp heptose; stories tryptophans ... See more keywords
Akkermansia muciniphila upregulates genes involved in maintaining the intestinal barrier function via ADP-heptose-dependent activation of the ALPK1/TIFA pathway
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2110639
Abstract: ABSTRACT The commensal bacteria that make up the gut microbiota impact the health of their host on multiple levels. In particular, the interactions taking place between the microbe-associated molecule patterns (MAMPs) and pattern recognition receptors… read more here.
Keywords: tifa; adp heptose; akkermansia muciniphila; genes involved ... See more keywords
Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Journal"
DOI: 10.1101/2022.07.19.500647
Abstract: ADP-heptose activates the protein kinase ALPK1 triggering TIFA phosphorylation at Thr9, the recruitment of TRAF6 and the subsequent production of inflammatory mediators. Here, we demonstrate that ADP-heptose also stimulates the formation of Lys63- and Met1-linked… read more here.
Keywords: traf2 iap1; adp heptose; traf6 traf2; ligases traf6 ... See more keywords