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Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11871
Abstract: Poly (ADP‐ribose) polymerase 1 (PARP1) is a typical representative of the PARP enzyme family and is mainly related to DNA repair, gene transcription regulation, inflammation, and oxidative stress. Studies have found that PARP1 is involved…
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Keywords:
apoptosis;
cma;
parp1;
degradation ... See more keywords
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Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29440
Abstract: Patients with metastatic and recurrent cervical cancer (CC) have a poor prognosis with limited palliative treatment options. Increasing understanding of the cellular aberrations inherent to cancer cells has allowed the development of therapies to target…
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Keywords:
cancer role;
poly adp;
cervical cancer;
ribose polymerase ... See more keywords
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Published in 2020 at "Journal of separation science"
DOI: 10.1002/jssc.202000856
Abstract: Yanghe decoction is a traditional Chinese medicine prescription and has been used for breast cancer treatment for many years. However, the effective ingredients in the decoction have not been identified. The expression of poly (ADP-ribose)…
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Keywords:
ribose polymerase;
medicine;
adp ribose;
poly adp ... See more keywords
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Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23535
Abstract: Methylmercury (MeHg) is an environmental neurotoxic substance, which can easily cross the blood–brain barrier, causing irreversible damage to the human central nervous system. Reactive oxygen species (ROS) are involved in various ways of intracellular physiological…
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Keywords:
reactive oxygen;
apoptosis;
oxygen species;
caspase ... See more keywords
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Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6993-7_11
Abstract: ADP-ribosylation is a posttranslational modification (PTM) that affects a variety of cellular processes. In recent years, mass spectrometry (MS)-based proteomics has become a valuable tool for studying ADP-ribosylation. However, studying this PTM in vivo in…
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Keywords:
adp ribose;
mass spectrometry;
ribose acceptor;
liquid chromatography ... See more keywords
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Published in 2019 at "Drugs"
DOI: 10.1007/s40265-019-01235-5
Abstract: The poly-(ADP-ribose) polymerase (PARP) inhibitors olaparib and talazoparib, have recently been approved for use in patients with metastatic breast cancer (BC) and germline BRCA 1 or 2 mutations due to improved progression-free survival compared to…
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Keywords:
poly adp;
brca mutations;
breast cancer;
ribose polymerase ... See more keywords
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Published in 2020 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2019.12.009
Abstract: Disruption of cellular functions with aging-induced accumulation of neuronal stressors causes cell death which is a common feature of neurodegenerative diseases. Studies in a variety of neurodegenerative disease models demonstrate that poly (ADP-ribose) (PAR)-dependent cell…
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Keywords:
death;
poly adp;
neurodegenerative diseases;
cell death ... See more keywords
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Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.04.022
Abstract: Natural products have been an invaluable source of drug discovery, but their targets remain largely unknown. Natural products enriched DNA-encoded chemical libraries (nDELs) empower the researchers to rapidly and economically screen numerous natural products against…
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Keywords:
poly adp;
dna;
natural products;
dna encoded ... See more keywords
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Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.06.004
Abstract: Poly(ADP-ribosyl)ation is a unique post-translational modification of proteins. The metabolism of poly(ADP-ribose) (PAR) is tightly regulated mainly by poly(ADP-ribose) polymerases (PARP) and poly(ADP-ribose) glycohydrolase (PARG). Accumulating evidence has suggested the biological functions of PAR metabolism…
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Keywords:
poly adp;
dna;
cancer;
parg ... See more keywords
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Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.01.018
Abstract: The nuclear protein poly(ADP-ribose) polymerases-1/2 (PARP-1/2) are involved in DNA repair damaged by endogenous or exogenous process. And PARP-1/2 inhibitors have been proved to be clinically efficacious for DNA repair deficient tumors in the past…
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Keywords:
parp inhibitors;
poly adp;
carboxamides novel;
parp ... See more keywords
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Published in 2019 at "Journal of Structural Biology"
DOI: 10.1016/j.jsb.2019.02.008
Abstract: Abstract Venezuelan equine encephalitis virus (VEEV) is a new world alphavirus which can be involved in several central nervous system disorders such as encephalitis and meningitis. The VEEV genome codes for 4 non-structural proteins (nsP),…
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Keywords:
binding adp;
macro domain;
veev;
macro ... See more keywords