Noncanonical mono(ADP-ribosyl)ation of zinc finger SZF proteins counteracts ubiquitination for protein homeostasis in plant immunity.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.09.006
Abstract: Protein ADP-ribosylation is a reversible post-translational modification that transfers ADP-ribose from NAD+ onto acceptor proteins. Poly(ADP-ribosyl)ation (PARylation), catalyzed by poly(ADP-ribose) polymerases (PARPs) and poly(ADP-ribose) glycohydrolases (PARGs), which remove the modification, regulates diverse cellular processes. However,… read more here.
Keywords: adp ribose; adp ribosyl; ribosyl ation; adp ... See more keywords
Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cell"
DOI: 10.1016/j.molcel.2022.01.020
Abstract: Synthetic lethality through combinatorial targeting DNA damage response (DDR) pathways provides exciting anticancer therapeutic benefit. Currently, the long noncoding RNAs (lncRNAs) have been implicated in tumor drug resistance; however, their potential significance in DDR is… read more here.
Keywords: ribosyl ation; poly adp; adp ribosyl; ctip ... See more keywords
PARP1 and Poly(ADP-ribosyl)ation Signaling during Autophagy in Response to Nutrient Deprivation
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/2641712
Abstract: Autophagy is considered to be the primary degradative pathway that takes place in all eukaryotic cells. Morphologically, the autophagy pathway refers to a process by which cytoplasmic portions are delivered to double-membrane organelles, called autophagosomes,… read more here.
Keywords: adp ribosyl; poly adp; ribosyl ation; adp ... See more keywords
ADP-Ribosylation and Antiviral Resistance in Plants
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DOI: 10.3390/v15010241
Abstract: ADP-ribosylation (ADPRylation) is a versatile posttranslational modification in eukaryotic cells which is involved in the regulation of a wide range of key biological processes, including DNA repair, cell signalling, programmed cell death, growth and development… read more here.
Keywords: adp ribosylation; ribosylation antiviral; antiviral resistance; adp ribosyl ... See more keywords
In silico identification and in vitro activity of natural products as ADP-ribosyl transferase member 8 inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2020-0138
Abstract: Aim: ADP-ribosyl transferase member 8 (ARTD8) of the ARTD superfamily has been identified as a possible anti-cancer, antiviral and anti-inflammatory target. Method: Pure actives from natural products with a documented anti-cancer activity were docked into… read more here.
Keywords: natural products; adp ribosyl; transferase member; ribosyl transferase ... See more keywords