Ric-8A-mediated stabilization of the trimeric G protein subunit Gαi is inhibited by pertussis toxin-catalyzed ADP-ribosylation.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.036
Abstract: The heterotrimeric G protein subunit Gαi can be activated by G protein-coupled receptors and the cytosolic protein Ric-8A, the latter of which is also known to prevent ubiquitin-dependent degradation of Gαi. Here we show that… read more here.
Keywords: protein; adp ribosylation; adp ribosylated; protein subunit ... See more keywords
Synthetic α- and β-Ser-ADP-ribosylated Peptides Reveal α-Ser-ADPr as the Native Epimer
Sign Up to like & getrecommendations! Published in 2018 at "Organic Letters"
DOI: 10.1021/acs.orglett.8b01742
Abstract: A solid-phase methodology to synthesize oligopeptides, specifically incorporating serine residues linked to ADP-ribose (ADPr), is presented. Through the synthesis of both α- and β-anomers of the phosphoribosylated Fmoc-Ser building block and their usage in our… read more here.
Keywords: adp ribosylated; ser adpr; ser; ser adp ... See more keywords
ADPriboDB 2.0: an updated database of ADP-ribosylated proteins
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa941
Abstract: Abstract ADP-ribosylation is a protein modification responsible for biological processes such as DNA repair, RNA regulation, cell cycle and biomolecular condensate formation. Dysregulation of ADP-ribosylation is implicated in cancer, neurodegeneration and viral infection. We developed… read more here.
Keywords: adp ribosylated; adp ribosylation; ribosylated proteins; database ... See more keywords