Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00281
Abstract: Major advances have recently defined functions for human mono-ADP-ribosylating PARP enzymes (mono-ARTs), also opening up potential applications for targeting them to treat diseases. Structural biology combined with medicinal chemistry has allowed the design of potent… read more here.
Keywords: adp ribosylating; medicinal chemistry; chemistry; chemistry perspective ... See more keywords
PARP14: A key ADP-ribosylating protein in host–virus interactions?
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010535
Abstract: Over 300 posttranslational modifications (PTMs) are known to modify the functions of proteins by affecting processes ranging from activation, degradation, localization, secretion, recognition, and regulation [1]. One such PTM, ADP-ribosylation, can be defined as the… read more here.
Keywords: ribosylating protein; adp ribosylating; key adp; protein host ... See more keywords