Structure-activity relationships for inhibitors of Pseudomonas aeruginosa exoenzyme S ADP-ribosyltransferase activity.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.11.036
Abstract: During infection, the Gram-negative opportunistic pathogen Pseudomonas aeruginosa employs its type III secretion system to translocate the toxin exoenzyme S (ExoS) into the eukaryotic host cell cytoplasm. ExoS is an essential in vivo virulence factor that… read more here.
Keywords: exoenzyme; pseudomonas aeruginosa; activity relationships; structure activity ... See more keywords
14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface
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DOI: 10.1038/s41467-018-06194-1
Abstract: Pseudomonas are a common cause of hospital-acquired infections that may be lethal. ADP-ribosyltransferase activities of Pseudomonas exotoxin-S and -T depend on 14-3-3 proteins inside the host cell. By binding in the 14-3-3 phosphopeptide binding groove,… read more here.
Keywords: proteins activate; toxin; activation; exotoxin ... See more keywords
ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP
Sign Up to like & getrecommendations! Published in 2019 at "Nature Microbiology"
DOI: 10.1038/s41564-019-0428-3
Abstract: Outbreaks of viral infections are a global health burden. Although type I interferon (IFN-I) exerts broad-spectrum antiviral effects, its antiviral efficacy in host cells is largely restricted by viruses. How the antiviral efficacy of IFN-I… read more here.
Keywords: ubiquitin ligase; ifn; adp ribosyltransferase; mono adp ... See more keywords
Broad-Spectrum Regulation of Nonreceptor Tyrosine Kinases by the Bacterial ADP-Ribosyltransferase EspJ
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DOI: 10.1128/mbio.00170-18
Abstract: ABSTRACT Tyrosine phosphorylation is key for signal transduction from exogenous stimuli, including the defense against pathogens. Conversely, pathogens can subvert protein phosphorylation to control host immune responses and facilitate invasion and dissemination. The bacterial effectors… read more here.
Keywords: bacterial adp; tyrosine; epec ehec; rodentium ... See more keywords
Development of Anti-Virulence Therapeutics against Mono-ADP-Ribosyltransferase Toxins
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DOI: 10.3390/toxins13010016
Abstract: Mono-ADP-ribosyltransferase toxins are often key virulence factors produced by pathogenic bacteria as tools to compromise the target host cell. These toxins are enzymes that use host cellular NAD+ as the substrate to modify a critical… read more here.
Keywords: virulence; anti virulence; ribosyltransferase toxins; adp ribosyltransferase ... See more keywords
Targeted silencing of the ADP-ribosyltransferase 3 gene inhibits the migration ability of melanoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2018.8252
Abstract: Melanoma is the most common primary intraocular malignancy and metastasis of melanoma to other organs often results in a poor prognosis. ADP-ribosyltransferase 3 (ART3) is involved in cell division and DNA repair. However, its biological… read more here.
Keywords: melanoma; melanoma cells; ability melanoma; gene ... See more keywords