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   Articles with "adp ribosyltransferase" as a keyword



Structure-activity relationships for inhibitors of Pseudomonas aeruginosa exoenzyme S ADP-ribosyltransferase activity.

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recommendations! Published in 2018 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2017.11.036

Abstract: During infection, the Gram-negative opportunistic pathogen Pseudomonas aeruginosa employs its type III secretion system to translocate the toxin exoenzyme S (ExoS) into the eukaryotic host cell cytoplasm. ExoS is an essential in vivo virulence factor that… read more here.

Keywords: exoenzyme; pseudomonas aeruginosa; activity relationships; structure activity ... See more keywords

14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface

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recommendations! Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-06194-1

Abstract: Pseudomonas are a common cause of hospital-acquired infections that may be lethal. ADP-ribosyltransferase activities of Pseudomonas exotoxin-S and -T depend on 14-3-3 proteins inside the host cell. By binding in the 14-3-3 phosphopeptide binding groove,… read more here.

Keywords: proteins activate; toxin; activation; exotoxin ... See more keywords

Thioredoxin 1 moonlights as a chaperone for an interbacterial ADP-ribosyltransferase toxin

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-54892-w

Abstract: Formation and breakage of disulfide bridges strongly impacts folding and activity of proteins. Thioredoxin 1 (TrxA) is a small, conserved enzyme that reduces disulfide bonds in the bacterial cytosol. In this study, we provide an… read more here.

Keywords: trex; ribosyltransferase toxin; ribosyltransferase; adp ribosyltransferase ... See more keywords

ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP

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recommendations! Published in 2019 at "Nature Microbiology"

DOI: 10.1038/s41564-019-0428-3

Abstract: Outbreaks of viral infections are a global health burden. Although type I interferon (IFN-I) exerts broad-spectrum antiviral effects, its antiviral efficacy in host cells is largely restricted by viruses. How the antiviral efficacy of IFN-I… read more here.

Keywords: ubiquitin ligase; ifn; adp ribosyltransferase; mono adp ... See more keywords

Anti-viral defence by an mRNA ADP-ribosyltransferase that blocks translation

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recommendations! Published in 2024 at "Nature"

DOI: 10.1038/s41586-024-08102-8

Abstract: Host–pathogen conflicts are crucibles of molecular innovation1,2. Selection for immunity to pathogens has driven the evolution of sophisticated immunity mechanisms throughout biology, including in bacterial defence against bacteriophages3. Here we characterize the widely distributed anti-phage… read more here.

Keywords: adp ribosyltransferase; viral defence; mrna; defence ... See more keywords

A deep learning method to predict bacterial ADP-ribosyltransferase toxins

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recommendations! Published in 2024 at "Bioinformatics"

DOI: 10.1093/bioinformatics/btae378

Abstract: Abstract Motivation ADP-ribosylation is a critical modification involved in regulating diverse cellular processes, including chromatin structure regulation, RNA transcription, and cell death. Bacterial ADP-ribosyltransferase toxins (bARTTs) serve as potent virulence factors that orchestrate the manipulation… read more here.

Keywords: deep learning; adp ribosyltransferase; bacterial adp; ribosyltransferase toxins ... See more keywords

Broad-Spectrum Regulation of Nonreceptor Tyrosine Kinases by the Bacterial ADP-Ribosyltransferase EspJ

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recommendations! Published in 2018 at "mBio"

DOI: 10.1128/mbio.00170-18

Abstract: ABSTRACT Tyrosine phosphorylation is key for signal transduction from exogenous stimuli, including the defense against pathogens. Conversely, pathogens can subvert protein phosphorylation to control host immune responses and facilitate invasion and dissemination. The bacterial effectors… read more here.

Keywords: bacterial adp; tyrosine; epec ehec; rodentium ... See more keywords
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Development of Anti-Virulence Therapeutics against Mono-ADP-Ribosyltransferase Toxins

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recommendations! Published in 2020 at "Toxins"

DOI: 10.3390/toxins13010016

Abstract: Mono-ADP-ribosyltransferase toxins are often key virulence factors produced by pathogenic bacteria as tools to compromise the target host cell. These toxins are enzymes that use host cellular NAD+ as the substrate to modify a critical… read more here.

Keywords: virulence; anti virulence; ribosyltransferase toxins; adp ribosyltransferase ... See more keywords

Targeted silencing of the ADP-ribosyltransferase 3 gene inhibits the migration ability of melanoma cells

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recommendations! Published in 2018 at "Oncology Letters"

DOI: 10.3892/ol.2018.8252

Abstract: Melanoma is the most common primary intraocular malignancy and metastasis of melanoma to other organs often results in a poor prognosis. ADP-ribosyltransferase 3 (ART3) is involved in cell division and DNA repair. However, its biological… read more here.

Keywords: melanoma; melanoma cells; ability melanoma; gene ... See more keywords