Eliciting the silent lucensomycin biosynthetic pathway in Streptomyces cyanogenus S136 via manipulation of the global regulatory gene adpA
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82934-6
Abstract: Actinobacteria are among the most prolific sources of medically and agriculturally important compounds, derived from their biosynthetic gene clusters (BGCs) for specialized (secondary) pathways of metabolism. Genomics witnesses that the majority of actinobacterial BGCs are… read more here.
Keywords: eliciting silent; streptomyces cyanogenus; cyanogenus s136; adpa ... See more keywords
A Novel AdpA Homologue Negatively Regulates Morphological Differentiation in Streptomyces xiamenensis 318
Sign Up to like & getrecommendations! Published in 2019 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.03107-18
Abstract: AdpA is a key regulator of secondary metabolism and morphological differentiation in Streptomyces species. However, AdpA had not been reported to negatively regulate morphological differentiation. Here, we characterized the regulatory role of AdpASx in Streptomyces… read more here.
Keywords: morphological differentiation; differentiation; gene; xiamenensis 318 ... See more keywords
The Pleiotropic Regulator AdpA Regulates the Removal of Excessive Sulfane Sulfur in Streptomyces coelicolor
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12020312
Abstract: Reactive sulfane sulfur (RSS), including persulfide, polysulfide, and elemental sulfur (S8), has important physiological functions, such as resisting antibiotics in Pseudomonas aeruginosa and Escherichia coli and regulating secondary metabolites production in Streptomyces spp. However, at… read more here.
Keywords: sulfane sulfur; adpa; regulator; rss ... See more keywords