Semaphorin 7A in circulating regulatory T cells is increased in autosomal-dominant polycystic kidney disease and decreases with tolvaptan treatment
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-018-1542-x
Abstract: BackgroundSemaphorin 7A (SEMA7A) is an immunomodulating protein implicated in lung and liver fibrosis. In autosomal-dominant polycystic kidney disease (ADPKD), the progressive expansion of renal cysts, inflammation, and subsequent renal fibrosis leads to end-stage renal disease… read more here.
Keywords: fibrosis; disease; expression; tolvaptan treatment ... See more keywords
Natural-derived compounds and their mechanisms in potential autosomal dominant polycystic kidney disease (ADPKD) treatment
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-021-02111-x
Abstract: Autosomal dominant polycystic kidney disease (ADPKD) is a monogenic kidney disorder that impairs renal functions progressively leading to kidney failure. The disease affects between 1:400 and 1:1000 ratio of the people worldwide. It is caused… read more here.
Keywords: disease; autosomal dominant; dominant polycystic; polycystic kidney ... See more keywords
Expanding the variability of the ADPKD-GANAB clinical phenotype in a family of Italian ancestry
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DOI: 10.1007/s40620-021-01131-w
Abstract: Causative mutations in the GANAB gene have been described in only 14 families, 9 diagnosed with late-onset Autosomal Dominant Polycystic Kidney Disease (ADPKD) and 5 with Autosomal Dominant Polycystic Liver Disease (ADPLD). Diagnosis of ADPKD… read more here.
Keywords: adpkd; ganab variant; family; adpkd ganab ... See more keywords
SO002INTERIM RESULTS FROM ACQUIRE: A STUDY MEASURING QUALITY OF LIFE, TREATMENT PREFERENCE AND TREATMENT SATISFACTION OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE PATIENTS IN EUROPE
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa139.so002
Abstract: Data suggest the health-related quality of life (HRQoL) of autosomal dominant polycystic kidney disease (ADPKD) patients (pts) may be lower than the general population [1,2]. In this ‘real life’ cohort of ADPKD pts with chronic… read more here.
Keywords: treatment; disease; treatment satisfaction; adpkd ... See more keywords
EPICARDIAL FAT THICKNESS IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCISTIC KIDNEY DISEASE
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DOI: 10.1097/01.hjh.0000539317.33948.c3
Abstract: Objective: Autosomal dominant polycystic kidney disease (ADPKD) is associated with early organ damage such as left ventricular hypertrophy (LVH) and higher cardiovascular risk when compared to essential hypertension (EH). Epicardial adipose tissue (EAT) is a… read more here.
Keywords: adpkd; autosomal dominant; eat; kidney disease ... See more keywords
Rapamycin treatment dose‐dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell‐cycle‐associated CDK1/cyclin axis
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DOI: 10.1111/jcmm.13091
Abstract: Although translational research into autosomal dominant polycystic kidney disease (ADPKD) and its pathogenesis has made considerable progress, there is presently lack of standardized animal model for preclinical trials. In this study, we developed an orthologous… read more here.
Keywords: adpkd; cyclin; model; cre ... See more keywords
The Pathophysiology of Left Ventricular Hypertrophy, beyond Hypertension, in Autosomal Dominant Polycystic Kidney Disease.
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DOI: 10.1159/000525944
Abstract: Heart disease is one of the leading causes of death in autosomal dominant polycystic kidney disease (ADPKD) patients. Left ventricular hypertrophy (LVH) is an early and severe complication in ADPKD patients. Two decades ago, the… read more here.
Keywords: disease; adpkd patients; lvh; autosomal dominant ... See more keywords
Identification of ACOT13 and PTGER2 as novel candidate genes of autosomal dominant polycystic kidney disease through whole exome sequencing
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DOI: 10.1186/s40001-021-00613-8
Abstract: Background Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic kidney disorder. Half of the patients would slowly progress to end-stage renal disease. However, the potential target for ADPKD treatment is still lacking.… read more here.
Keywords: adpkd; autosomal dominant; dominant polycystic; polycystic kidney ... See more keywords
Rapidly Progressing to ESRD in an Individual with Coexisting ADPKD and Masked Klinefelter and Gitelman Syndromes
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DOI: 10.3390/genes13030394
Abstract: Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenetic hereditary renal disease, promoting end-stage renal disease (ESRD). Klinefelter syndrome (KS) is a consequence of an extra copy of the X chromosome in males.… read more here.
Keywords: individual coexisting; coexisting adpkd; progressing esrd; rapidly progressing ... See more keywords
Identification and Characterization of Novel Mutations in Chronic Kidney Disease (CKD) and Autosomal Dominant Polycystic Kidney Disease (ADPKD) in Saudi Subjects by Whole-Exome Sequencing
Sign Up to like & getrecommendations! Published in 2022 at "Medicina"
DOI: 10.3390/medicina58111657
Abstract: Background: Autosomal dominant polycystic kidney disease (ADPKD) is a condition usually caused by a single gene mutation and manifested by both renal and extrarenal features, eventually leading to end-stage renal disease (ESRD) by the median… read more here.
Keywords: disease; chronic kidney; kidney disease; gene ... See more keywords