Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR
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DOI: 10.1038/s41598-019-41531-4
Abstract: NvTRPM2 (Nematostella vectensis Transient Receptor Potential Melastatin 2), the species variant of the human apoptosis-related cation channel hTRPM2, is gated by ADP-ribose (ADPR) independently of the C-terminal NUDT9H domain that mediates ADPR-directed gating in hTRPM2.… read more here.
Keywords: different substrate; adpr binding; site; substrate specificities ... See more keywords
Functional importance of NUDT9H domain and N-terminal ADPR-binding pocket in two species variants of vertebrate TRPM2 channels
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DOI: 10.1038/s41598-019-55232-5
Abstract: There are at least two different principles of how ADP-ribose (ADPR) induces activation of TRPM2 channels. In human TRPM2, gating requires the C-terminal NUDT9H domain as ADPR-binding module, whereas in sea anemone, NUDT9H is dispensable… read more here.
Keywords: terminal adpr; adpr; binding pocket; adpr binding ... See more keywords