Development of oxoisoaporphine derivatives with topoisomerase I inhibition and reversal of multidrug resistance in breast cancer MCF-7/ADR cells.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114300
Abstract: A series of oxoisoaporphine derivatives with topoisomerase I inhibition and cytotoxic activities. Among them, compound 14 showed the most potent cytotoxic activity against all cancer cell lines tested, and substantially lower cytotoxicity to LO2 cells.… read more here.
Keywords: adr cells; inhibition; cancer; mcf adr ... See more keywords
7-O-geranylquercetin contributes to reverse P-gp-mediated adriamycin resistance in breast cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116938
Abstract: AIMS To investigate the effect of 7-O-geranylquercetin (GQ), a derivative of quercetin (Q), on reversing drug resistance in breast cancer MCF-7/ADR cells and reveal the mechanisms related to P-glycoprotein (P-gp). MAIN METHODS Cell viability was… read more here.
Keywords: drug resistance; mcf adr; adr cells; resistance ... See more keywords
Neo-clerodane diterpenoids from Scutellaria barbata and their reversal multidrug resistance activity in HepG2/Adr cells
Sign Up to like & getrecommendations! Published in 2020 at "Phytochemistry Letters"
DOI: 10.1016/j.phytol.2019.11.014
Abstract: Abstract Bioassay-guided isolation of the aerial part of Scutellaria barbata (Labiatae) yielded six new neo-clerodane diterpenoids scutegxbatines A–F (1-6), together with thirteen known analogues (7-20). Their structures were elucidated on the basis of extensive spectroscopic… read more here.
Keywords: clerodane diterpenoids; hepg2 adr; neo clerodane; adr cells ... See more keywords
Molecular Mechanism of Matrine from Sophora alopecuroides in the Reversing Effect of Multi-Anticancer Drug Resistance in K562/ADR Cells
Sign Up to like & getrecommendations! Published in 2019 at "BioMed Research International"
DOI: 10.1155/2019/1269532
Abstract: Multidrug resistance is the main obstacle to current chemotherapies. In this study, we evaluated the reversing effect of matrine, the principal alkaloid derived from Sophora alopecuroides, on chemoresistant leukemia K562/ADR cells. Matrine in a range… read more here.
Keywords: k562 adr; matrine; drug; effect ... See more keywords
Nano-carrier Polyamidoamine Dendrimer G4 Induces Mitochondrial-dependent Apoptosis in Human Multidrug-resistant Breast Cancer Cells through G0/G1 Phase Arrest.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201023666220822150050
Abstract: BACKGROUND Multidrug-resistant tumor cells have special drug detoxification/inactivation mechanisms. The terminal amino groups of the polyamidoamine (PAMAM-NH2), which is cytotoxic to tumor sensitive cells, may have no cytotoxicity in tumor resistant cells with mechanism different… read more here.
Keywords: adr cells; pamam nh2; multidrug resistant; mcf adr ... See more keywords
Downregulation of eIF4G by microRNA-503 enhances drug sensitivity of MCF-7/ADR cells through suppressing the expression of ABC transport proteins
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Letters"
DOI: 10.3892/ol.2017.6049
Abstract: Overexpression of adenosine triphosphate-binding cassette (ABC) transport protein is emerging as a critical contributor to anticancer drug resistance. The eukaryotic translation initiation factor (eIF) 4F complex, the key modulator of mRNA translation, is regulated by… read more here.
Keywords: drug; adr cells; mcf adr; abc ... See more keywords