Protocatechuic acid mitigates adriamycin-induced reproductive toxicities and hepatocellular damage in rats
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DOI: 10.1007/s00580-018-2794-2
Abstract: Adriamycin (ADR) is an anticancer drug that has a wide report of toxicity in various organs including testes and liver. This has brought limitation to its use in chemotherapy. Protocatechuic acid (PCA) is a phenolic… read more here.
Keywords: group; protocatechuic acid; testes liver; adr induced ... See more keywords
miR-16-5p Regulates Ferroptosis by Targeting SLC7A11 in Adriamycin-Induced Ferroptosis in Cardiomyocytes
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DOI: 10.2147/jir.s393646
Abstract: Introduction Adriamycin (ADR) is commonly used in tumor chemotherapy, but its nonreversible cardiotoxicity severely hampers its clinical application. Ferroptosis is an implicated cause of ADR-induced injury. However, the underlying molecular mechanisms remain poorly understood. This… read more here.
Keywords: adr induced; adriamycin; cardiotoxicity; adr ... See more keywords
Fasudil protects against adriamycin-induced acute heart injury by inhibiting oxidative stress, apoptosis and cellular senescence.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical design"
DOI: 10.2174/1381612828666220729103430
Abstract: BACKGROUND The clinical utility of Adriamycin (ADR) is limited due to its toxicity, particularly cardiotoxicity. Therefore, effective cardioprotective adjuvants to minimize ADR-induced acute cardiotoxicity are urgently needed. Our previous studies have demonstrated protective roles of… read more here.
Keywords: fasudil; adr induced; induced acute; senescence ... See more keywords
Apoptosis and remodeling in adriamycin-induced cardiomyopathy rat model
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DOI: 10.3345/kjp.2017.60.11.365
Abstract: Purpose The mechanism for the pathogenesis of adriamycin (ADR)-induced cardiomyopathy is not yet known. Different hypotheses include the production of free radicals, an interaction between ADR and nuclear components, and a disruption in cardiac-specific gene… read more here.
Keywords: collagen; adriamycin; group; adr induced ... See more keywords