Comparative assessment of hypothalamic-pituitary-adrenal axis suppression secondary to intrabursal injection of different glucocorticoids: a pilot study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-019-01033-6
Abstract: AbstractBackground Hypothalamic-pituitary-adrenal axis (HPAA) suppression is the most common and dangerous, although often unrecognized and untreated, side effect of glucocorticoid administration. The risk and duration depend both on patient and treatment characteristics. High-performance liquid chromatography-tandem… read more here.
Keywords: suppression; hypothalamic pituitary; pituitary adrenal; adrenal axis ... See more keywords
Noncanonical genomic imprinting in the monoamine system determines naturalistic foraging and brain-adrenal axis functions.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110500
Abstract: Noncanonical genomic imprinting can cause biased expression of one parental allele in a tissue; however, the functional relevance of such biases is unclear. To investigate ethological roles for noncanonical imprinting in dopa decarboxylase (Ddc) and… read more here.
Keywords: noncanonical genomic; naturalistic foraging; genomic imprinting; brain adrenal ... See more keywords
Stress-related over-enhancement of the hypothalamic-pituitary-adrenal axis causes experimental neurolathyrism in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2019.103245
Abstract: Neurolathyrism is a motor neuron disease that is caused by the overconsumption of grass peas (Lathyrus sativus L.) under stressful conditions. The neuro-excitatory β-N-oxalyl-L-α,β-diaminopropionic acid present in grass peas was proposed the causative agent of… read more here.
Keywords: neurolathyrism; hypothalamic pituitary; pituitary adrenal; stress ... See more keywords
Ketamine and Etomidate Down-regulate the Hypothalamic-Pituitary-Adrenal Axis in an Endotoxemic Mouse Model.
Sign Up to like & getrecommendations! Published in 2017 at "Anesthesiology"
DOI: 10.1097/aln.0000000000001704
Abstract: BACKGROUND We compared the effects of etomidate and ketamine on the hypothalamic-pituitary-adrenal axis during sepsis. METHODS Mice (n = 5/group) were injected intraperitoneally with lipopolysaccharide (10 mg/kg) and 6 h later randomized to receive ketamine (100 mg/kg), etomidate… read more here.
Keywords: pituitary adrenal; hypothalamic pituitary; adrenal axis; ketamine etomidate ... See more keywords
Psychosocial Stress and Hypothalamic-Pituitary-Adrenal Axis Stress Reactivity: Variations by Race and Socioeconomic Status Among Adults at Risk of Diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Psychosomatic Medicine"
DOI: 10.1097/psy.0000000000001112
Abstract: ABSTRACT Objective Although stress is posited to play a key role in health disparities, the extent to which commonly used self-report psychosocial stress measures are related to neurobiological stress processes, especially across diverse populations, is… read more here.
Keywords: stress; hypothalamic pituitary; adrenal axis; pituitary adrenal ... See more keywords
Icariin inhibits inflammation via immunomodulation of the cutaneous hypothalamus–pituitary–adrenal axis in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.13735
Abstract: Dysfunction of skin steroidogenesis plays an important role in inflammatory skin diseases. We previously carried out an animal study which showed that icariin could inhibit the inflammation of atopic dermatitis by regulating the cutaneous hypothalamus–pituitary–adrenal… read more here.
Keywords: hypothalamus pituitary; cutaneous hypothalamus; adrenal axis; pituitary adrenal ... See more keywords
Stress and the hypothalamic-pituitary-adrenal axis: How can the COVID-19 pandemic inform our understanding and treatment of acute insomnia?
Sign Up to like & getrecommendations! Published in 2023 at "Journal of sleep research"
DOI: 10.1111/jsr.13842
Abstract: Stress and sleep are very closely linked, and stressful life events can trigger acute insomnia. The ongoing COVID-19 pandemic is highly likely to represent one such stressful life event. Indeed, a wide range of cross-sectional… read more here.
Keywords: hypothalamic pituitary; adrenal axis; insomnia; acute insomnia ... See more keywords
Hypothalamic‐pituitary‐adrenal axis suppression in asthma: A glucocorticoid receptor polymorphism may protect
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric Allergy and Immunology"
DOI: 10.1111/pai.13379
Abstract: Asthmatic children on corticosteroids can develop hypothalamic‐pituitary‐adrenal axis suppression (HPAS). Single nucleotide polymorphisms (SNPs) rs242941 and rs1876828 of the corticotrophin‐releasing hormone receptor 1 (CRHR1) gene were associated with lower stimulated cortisol (F) levels, whereas rs41423247… read more here.
Keywords: hypothalamic pituitary; pituitary adrenal; adrenal axis; axis suppression ... See more keywords
The Hypothalamic-Pituitary-Adrenal Axis: A Brief History
Sign Up to like & getrecommendations! Published in 2018 at "Hormone Research in Paediatrics"
DOI: 10.1159/000487755
Abstract: The hypothalamic-pituitary-adrenal (HPA) axis is central to homeostasis, stress responses, energy metabolism, and neuropsychiatric function. The history of this complex system involves discovery of the relevant glands (adrenal, pituitary, hypothalamus), hormones (cortisol, corticotropin, corticotropin-releasing hormone),… read more here.
Keywords: hypothalamic pituitary; pituitary adrenal; axis brief; history ... See more keywords
Cannabidiol regulates the expression of hypothalamus-pituitary-adrenal axis-related genes in response to acute restraint stress
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Psychopharmacology"
DOI: 10.1177/0269881118805495
Abstract: Background: Research interest has grown around the potential therapeutic use of cannabidiol in mood-related disorders, due to its anxiolytic and antidepressant-like effects. These have been partially attributed to its action as an allosteric modulator of… read more here.
Keywords: hypothalamus pituitary; pituitary adrenal; stress; adrenal axis ... See more keywords
Electroacupuncture alleviates perioperative hypothalamus-pituitary-adrenal axis dysfunction via circRNA-miRNA-mRNA networks
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1115569
Abstract: Electroacupuncture (EA) has long been used to alleviate surgery-induced hypothalamic–pituitary–adrenal axis dysfunction. However, its downstream gene targets in the brain remain unclear. The aim of the present study was to clarify the potential targets of… read more here.
Keywords: circrna mirna; mirna mrna; adrenal axis; pituitary adrenal ... See more keywords