Renal tubular and adrenal medullary tumors in the 2-year rat study with canagliflozin confirmed to be secondary to carbohydrate (glucose) malabsorption in the 15-month mechanistic rat study.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.09.008
Abstract: During preclinical development of canagliflozin, an SGLT2 inhibitor, treatment-related pheochromocytomas, renal tubular tumors (RTT), and testicular Leydig cell tumors were reported in the 2-year rat toxicology study. In a previous 6-month rat mechanistic study, feeding… read more here.
Keywords: rat study; malabsorption; adrenal medullary; canagliflozin ... See more keywords
Adrenal medullary dysfunction as a feature of obesity
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Obesity"
DOI: 10.1038/ijo.2017.36
Abstract: Background and Objective:Although there is strong evidence linking obesity with increased sympathoneural activity, involvement of the adrenal medulla is less clear. We therefore investigated adrenal medullary function under fasting and feeding conditions in normal weight… read more here.
Keywords: epinephrine; obesity; dysfunction; adrenal medullary ... See more keywords
Adrenal medullary hyperplasia mimicking pheochromocytoma
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DOI: 10.1136/bcr-2020-236209
Abstract: A 59-year-old woman, a known case of hypertension, was incidentally diagnosed with a large right-sided adrenal mass. Investigations for a functional adrenal lesion resulted in very high preoperative norepinephrine levels. A right adrenalectomy was performed.… read more here.
Keywords: hyperplasia mimicking; mimicking pheochromocytoma; medullary hyperplasia; adrenal medullary ... See more keywords
Presentation, Treatment, Histology, and Outcomes in Adrenal Medullary Hyperplasia Compared With Pheochromocytoma
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DOI: 10.1210/js.2019-00200
Abstract: Abstract Context Information about adrenal medullary hyperplasia (AMH) is scarce. Objective To study a large cohort of AMHs. Design, Setting, and Participants Nineteen AMH cases were compared with 95 pheochromocytomas (PCCs) without AMH. AMH without… read more here.
Keywords: amhs; pcc; medullary hyperplasia; adrenal medullary ... See more keywords
Nerve growth factor causes epinephrine release dysfunction by regulating phenotype alterations and the function of adrenal medullary chromaffin cells in mice with allergic rhinitis
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2023.12926
Abstract: The presence of allergic rhinitis (AR) is an increased risk factor for the occurrence of bronchial asthma (BA). Nerve growth factor (NGF), in addition to its key role in the development and differentiation of neurons,… read more here.
Keywords: medullary chromaffin; factor; nerve growth; growth factor ... See more keywords
Correlation between CT features of adrenocortical and adrenal medullary tumors and expression of miR-96 in serum
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DOI: 10.3892/ol.2018.8863
Abstract: Correlation between CT features of adrenocortical and adrenal medullary tumors and the expression of miR-96 in serum were investigated. A total of 230 patients with adrenocortical tumors and 194 patients with adrenal medullary tumors were… read more here.
Keywords: medullary tumors; serum; adrenocortical adrenal; adrenal medullary ... See more keywords