Toxic effects of triptolide on adrenal steroidogenesis in H295R cells and female rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22394
Abstract: Triptolide (TP), a major active ingredient of Tripterygium wilfordii, exerts potent immunosuppressive effects in the treatment of rheumatoid arthritis but is not widely used in clinical practice due to its multiorgan toxicity, particularly hepatotoxicity, nephrotoxicity,… read more here.
Keywords: triptolide adrenal; adrenal steroidogenesis; h295r; h295r cells ... See more keywords
Insulin Regulates Adrenal Steroidogenesis by Stabilizing SF-1 Activity
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DOI: 10.1038/s41598-018-23298-2
Abstract: Development of metabolic syndrome is associated with hyperactivity of the HPA axis characterized by elevated levels of circulating adrenal hormones including cortisol and aldosterone. However, the molecular mechanism leading to the dysregulation of the HPA… read more here.
Keywords: insulin; adrenal steroidogenesis; regulates adrenal; insulin regulates ... See more keywords
MECHANISMS IN ENDOCRINOLOGY: Rare defects in adrenal steroidogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of endocrinology"
DOI: 10.1530/eje-18-0279
Abstract: Congenital adrenal hyperplasia (CAH) is a group of genetic disorders of adrenal steroidogenesis that impair cortisol synthesis, with compensatory increases in ACTH leading to hyperplastic adrenals. The term 'CAH' is generally used to mean 'steroid… read more here.
Keywords: rare defects; adrenal steroidogenesis; endocrinology; steroidogenesis ... See more keywords