Overexpression of endothelial β3‐adrenergic receptor induces diastolic dysfunction in rats
Sign Up to like & getrecommendations! Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13040
Abstract: Diastolic dysfunction is common in cardiovascular diseases, particularly in the case of heart failure with preserved ejection fraction. The challenge is to develop adequate animal models to envision human therapies in the future. It has… read more here.
Keywords: receptor induces; dysfunction; overexpression endothelial; endothelial adrenergic ... See more keywords
Norepinephrine stimulation downregulates the β2‐adrenergic receptor–nitric oxide pathway in human pulmonary artery endothelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27057
Abstract: Norepinephrine (NE)‐mediated vasoconstriction plays an important role in pulmonary hypertension associated with left heart disease (PH‐LHD). However, the role of NE‐mediated endothelial cell dysfunction in the pathogenesis of PH‐LHD remains to be elucidated. read more here.
Keywords: norepinephrine stimulation; downregulates adrenergic; receptor nitric; stimulation downregulates ... See more keywords
Pharmacophore-guided Virtual Screening to Identify New β3-Adrenergic Receptor Agonists.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular informatics"
DOI: 10.1002/minf.202100223
Abstract: The β3-adrenergic receptor (β3-AR) is found in several tissues such as adipose tissue and urinary bladder. It is a therapeutic target because it plays a role in thermogenesis, lipolysis, and bladder relaxation. Two β3-AR agonists… read more here.
Keywords: adrenergic receptor; screening; pharmacophore guided; virtual screening ... See more keywords
Combined treatment with a β3‐adrenergic receptor agonist and a muscarinic receptor antagonist inhibits detrusor overactivity induced by cold stress in spontaneously hypertensive rats
Sign Up to like & getrecommendations! Published in 2017 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.23061
Abstract: This study determined if combined treatment with the muscarinic receptor (MR) antagonist solifenacin and the β3‐adrenergic receptor (AR) agonist mirabegron could inhibit detrusor overactivity induced by cold stress in spontaneously hypertensive rats (SHRs). read more here.
Keywords: receptor antagonist; receptor agonist; muscarinic receptor; receptor ... See more keywords
The effect of doxazosin and sildenafil citrate combination on bladder tissue contractility, alpha adrenergic receptor, and iNOS subtype expression in a male rat model of partially bladder outlet obstruction
Sign Up to like & getrecommendations! Published in 2017 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.23155
Abstract: Our aim was to investigate the effects of doxazosin, sildenafil, and their combination on bladder tissue contractility and adrenergic receptor (AR) and inducible nitric oxide synthase (iNOS) expression utilizing a male rat model of partial… read more here.
Keywords: combination bladder; male rat; tissue contractility; doxazosin sildenafil ... See more keywords
Role of β‐3 adrenergic receptor polymorphism in overactive bladder
Sign Up to like & getrecommendations! Published in 2019 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.24006
Abstract: Women with overactive bladder (OAB) have a higher frequency of a single‐nucleotide polymorphism (SNP) at codon 64 of the β‐3 adrenergic receptor gene (ADRB3). Since the SNP results in an amino acid substitution that could… read more here.
Keywords: overactive bladder; role adrenergic; receptor; adrenergic receptor ... See more keywords
Leveraging β-Adrenergic Receptor Signaling Blockade for Improved Cancer Immunotherapy Through Biomimetic Nanovaccine.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202207029
Abstract: The establishment of effective antitumor immune responses of vaccines is mainly limited by insufficient priming tumor infiltration of T cells and immunosuppressive tumor microenvironment (TME). Targeting β-adrenergic receptor (β-AR) signaling exerts promising benefits on reversing… read more here.
Keywords: biomimetic nanovaccine; receptor signaling; adrenergic receptor; tumor ... See more keywords
Voltammetric hybridization assay for the β1-adrenergic receptor gene (ADRB1), a marker for hypertension, by using a metal organic framework (Fe-MIL-88NH2) with immobilized copper(II) ions
Sign Up to like & getrecommendations! Published in 2017 at "Mikrochimica Acta"
DOI: 10.1007/s00604-017-2333-x
Abstract: The β1 receptor blocker metoprolol targets the hypertension-carrying adrenergic receptor gene (ADRB1), but therapy is often hindered by a lack of evidence-based medical information. The authors describe an assay for the ADRB1 gene. It is… read more here.
Keywords: receptor gene; metal organic; gene adrb1; receptor ... See more keywords
Effect of Clonidine Hydrochloride on Isolated Newborn Rat Heart.
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of experimental biology and medicine"
DOI: 10.1007/s10517-021-05347-5
Abstract: The concentration dependenies of the chronotropic response and changes in blood supply to the isolated heart of 7-day-old newborn rats induced by application of α2-adrenergic receptor agonist clonidine hydrochloride in concentrations of 10-9-10-6 M were… read more here.
Keywords: adrenergic receptor; concentration; heart; receptor agonist ... See more keywords
Cell therapy rescues aging-induced beta-1 adrenergic receptor and GRK2 dysfunction in the coronary microcirculation.
Sign Up to like & getrecommendations! Published in 2021 at "GeroScience"
DOI: 10.1007/s11357-021-00455-6
Abstract: Our past study showed that coronary arterioles isolated from adipose-derived stromal vascular fraction (SVF)-treated rats showed amelioration of the age-related decrease in vasodilation to beta-adrenergic receptor (β-AR) agonist and improved β-AR-dependent coronary flow and microvascular… read more here.
Keywords: vasodilation; grk2; svf; receptor ... See more keywords
Src mediates β-adrenergic receptor induced YAP tyrosine phosphorylation
Sign Up to like & getrecommendations! Published in 2020 at "Science China Life Sciences"
DOI: 10.1007/s11427-020-1652-9
Abstract: The Hippo pathway is a newly identified pathway and evolutionarily conserved from flies to humans mainly regulating cell proliferation. Transcriptional co-activator Yes-associated protein (YAP) functions as a major downstream effector and key node of the… read more here.
Keywords: tyrosine phosphorylation; src; adrenergic receptor; phosphorylation ... See more keywords