Cardiac beta3‐adrenergic receptors in the clinical arena: the end of the beginning
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.784
Abstract: Despite significant advances in treatment options, heart failure remains a devastating disease with significant morbidity/mortality and economic burden. In this context, new therapeutic approaches are eagerly needed. The paper by Bundgaard in this issue of… read more here.
Keywords: beta3 adrenergic; receptors clinical; cardiac beta3; adrenergic receptors ... See more keywords
Norepinephrine activates β1‐adrenergic receptors at the inner nuclear membrane in astrocytes
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24219
Abstract: Norepinephrine exerts powerful influences on the metabolic, neuroprotective and immunoregulatory functions of astrocytes. Until recently, all effects of norepinephrine were believed to be mediated by receptors localized exclusively to the plasma membrane. However, recent studies… read more here.
Keywords: inner nuclear; receptors localized; nuclear membrane; adrenergic receptors ... See more keywords
The role of β‐adrenergic receptors and p38MAPK signaling pathways in physiological processes of cardiosphere‐derived cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26292
Abstract: The effects of β adrenergic receptors (β‐ARs) and p38 mitogen‐activated protein kinases (MAPK) pathways on cardiosphere‐derived cells (CDCs) are largely unknown. This study aimed to investigate the roles of β‐ARs and p38MAPK pathways on the… read more here.
Keywords: p38mapk signaling; signaling pathways; adrenergic receptors; group ... See more keywords
Increased Atrial β-Adrenergic Receptors and GRK-2 Gene Expression Can Play a Fundamental Role in Heart Failure After Repair of Congenital Heart Disease with Cardiopulmonary Bypass
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Cardiology"
DOI: 10.1007/s00246-017-1573-1
Abstract: Surgeries to correct congenital heart diseases are increasing in Brazil and worldwide. However, even with the advances in surgical techniques and perfusion, some cases, especially the more complex ones, can develop heart failure and death.… read more here.
Keywords: heart; adrenergic receptors; heart failure; receptors grk ... See more keywords
Agonistic autoantibodies against B2-adrenergic receptors correlating with macrovascular disease in longstanding diabetes type 2
Sign Up to like & getrecommendations! Published in 2019 at "Acta Diabetologica"
DOI: 10.1007/s00592-019-01296-8
Abstract: AimsAgonistic autoantibodies directed against adrenergic, endothelin, and angiotensin receptors are known as pathogenic factors in disease-causing vascular impairments such as Buergers’ disease, dilatative cardiomyopathy, dementia, and preeclampsia. Diabetes mellitus also causes micro- and macrovascular damages,… read more here.
Keywords: agonistic autoantibodies; adrenergic receptors; prevalence; diabetes mellitus ... See more keywords
CCL2 Induces the Production of β2 Adrenergic Receptors and Modifies Astrocytic Responses to Noradrenaline
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0960-9
Abstract: The decline in brain noradrenaline levels is associated with the progression of certain neurodegenerative diseases. This seems to be due, at least in part, to the ability of noradrenaline to limit glial activation and to… read more here.
Keywords: ccl2 induces; production; adrenergic receptors; induces production ... See more keywords
Biased agonism at β-adrenergic receptors.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109905
Abstract: The β-adrenergic receptors (βARs) include three subtypes, β1, β2 and β3. These receptors are widely expressed and regulate numerous physiological processes including cardiovascular and metabolic functions and airway tone. The βARs are also important targets… read more here.
Keywords: adrenergic receptors; biased agonism; agonism adrenergic;
Structural Basis of the Diversity of Adrenergic Receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.10.088
Abstract: Adrenergic receptors are highly homologous while at the same time display a wide diversity of ligand and G-protein binding, and understanding this diversity is key for designing selective or biased drugs for them. Here, we… read more here.
Keywords: protein; structural basis; diversity; adrenergic receptors ... See more keywords
β-adrenergic receptors reduce the threshold for induction and stabilization of LTP and enhance its magnitude via multiple mechanisms in the ventral but not the dorsal hippocampus
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2018.04.010
Abstract: Graphical abstract Figure. No caption available. Highlights&bgr;‐adrenergic receptors (&bgr;‐ARs) modulate synaptic plasticity and emotional memory.LTP was induced at dorsal and ventral hippocampal slices (DH‐VH) by theta‐bursts.We found that the &bgr;‐AR modulation of LTP is strikingly… read more here.
Keywords: ltp; bgr; hippocampus; bgr ars ... See more keywords
Discovery of Environment-Sensitive Fluorescent Ligands of β-Adrenergic Receptors for Cell Imaging and NanoBRET Assay.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c05646
Abstract: By fusing several environment-sensitive fluorophores to the pharmacophore mirabegron, a series of new fluorescent ligands for β-adrenergic receptors (β-ARs) were produced with a turn-on mechanism and high binding affinity to β-ARs efficiently. Compound L5 with… read more here.
Keywords: ligands adrenergic; fluorescent ligands; environment; environment sensitive ... See more keywords
Duloxetine and Amitriptyline Reduce Neuropathic Pain by Inhibiting Primary Sensory Input to Spinal Dorsal Horn Neurons via α1- and α2-Adrenergic Receptors.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00780
Abstract: Antidepressants, such as duloxetine and amitriptyline, are effective for treating patients with chronic neuropathic pain. Inhibiting norepinephrine and serotonin transporters at presynaptic terminals raises extracellular concentrations of norepinephrine. The α1- and α2-adrenergic receptor agonists inhibit… read more here.
Keywords: duloxetine amitriptyline; effect; neuropathic pain; adrenergic receptors ... See more keywords