PEX1 is a mediator of α1‐adrenergic signaling attenuating doxorubicin‐induced cardiotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23196
Abstract: Doxorubicin (DOX) is a potent chemotherapeutic agent used for cancer treatment, however, DOX‐induced cardiotoxicity is a serious clinical problem because it causes acute and chronic heart dysfunction. Many studies have indicated that the α1‐adrenergic receptor… read more here.
Keywords: induced cardiotoxicity; pex1; adrenergic signaling; dox induced ... See more keywords
Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss
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DOI: 10.1016/j.cell.2019.12.002
Abstract: Enteric-associated neurons (EANs) are closely associated with immune cells and continuously monitor and modulate homeostatic intestinal functions, including motility and nutrient sensing. Bidirectional interactions between neuronal and immune cells are altered during disease processes such… read more here.
Keywords: signaling muscularis; infection; muscularis macrophages; infection induced ... See more keywords
Cardiac voltage gated calcium channels and their regulation by &bgr;‐adrenergic signaling
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.12.033
Abstract: &NA; Voltage‐gated calcium channels (VGCCs) are the predominant source of calcium influx in the heart leading to calcium‐induced calcium release and ultimately excitation‐contraction coupling. In the heart, VGCCs are modulated by the &bgr;‐adrenergic signaling. Signaling… read more here.
Keywords: heart; bgr adrenergic; heart failure; calcium ... See more keywords
Venlafaxine-induced adrenergic signaling stimulates Leydig cells steroidogenesis via Nur77 overexpression: a possible role of EGF.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.120069
Abstract: Venlafaxine, a norepinephrine and serotonin reuptake inhibitor, impairs rat sperm parameters, spermatogenesis and causes high intratesticular estrogen and testosterone levels, indicating that Leydig cells (LCs) may be a venlafaxine target. We evaluated the effect of… read more here.
Keywords: egf; venlafaxine; venlafaxine induced; steroidogenesis ... See more keywords
Beta2‐adrenergic signaling affects the phenotype of human cardiac progenitor cells through EMT modulation
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2017.01.016
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Human cardiac progenitor cells (CPCs) offer great promises to cardiac cell therapy for heart failure. Many in vivo studies have shown their therapeutic benefits, paving the way for… read more here.
Keywords: modulation; progenitor cells; bgr; cardiac progenitor ... See more keywords
Beta-adrenergic signaling promotes tumor angiogenesis and prostate cancer progression through HDAC2-mediated suppression of thrombospondin-1
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.319
Abstract: Chronic behavioral stress and beta-adrenergic signaling have been shown to promote cancer progression, whose underlying mechanisms are largely unclear, especially the involvement of epigenetic regulation. Histone deacetylase-2 (HDAC2), an epigenetic regulator, is critical for stress-induced… read more here.
Keywords: adrenergic signaling; beta adrenergic; cancer progression;
P738The restoration effect of metformin on the beta-adrenergic signaling, amp-activated kinase and akt-kinase in the myocardium of diabetic rats
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz747.0342
Abstract: The type 2 diabetic mellitus (DM2) induces the myocardial dysfunctions, the impairment of beta-adrenergic regulations and the alterations of energy homeostasis and apoptotic processes in the myocardium are the main causes of diabetic cardiomyopathy. Metformin… read more here.
Keywords: kinase; effect; akt kinase; diabetic rats ... See more keywords
Chronic Adrenergic Signaling Causes Abnormal RNA Expression of Proliferative Genes in Fetal Sheep Islets
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2018-00540
Abstract: Intrauterine growth restriction (IUGR) increases the risk of developing diabetes in later life, which indicates developmental programming of islets. IUGR fetuses with placental insufficiency develop hypoxemia, elevating epinephrine and norepinephrine (NE) concentrations throughout late gestation.… read more here.
Keywords: chronic adrenergic; islets chronic; expression; expressed genes ... See more keywords
β-adrenergic signaling broadly contributes to LTP induction
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DOI: 10.1371/journal.pcbi.1005657
Abstract: Long-lasting forms of long-term potentiation (LTP) represent one of the major cellular mechanisms underlying learning and memory. One of the fundamental questions in the field of LTP is why different molecules are critical for long-lasting… read more here.
Keywords: lasting ltp; signaling broadly; lasting forms; long lasting ... See more keywords
Adrenergic Signaling at the Interface of Allergic Asthma and Viral Infections
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00736
Abstract: Upper respiratory viral infections are a major etiologic instigator of allergic asthma, and they drive severe exacerbations of allergic inflammation in the lower airways of asthma sufferers. Rhinovirus (RV), in particular, is the main viral… read more here.
Keywords: interface allergic; viral infections; signaling interface; adrenergic signaling ... See more keywords