Association of Generalized Anxiety Disorder With Autonomic Hypersensitivity and Blunted Ventromedial Prefrontal Cortex Activity During Peripheral Adrenergic Stimulation
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2021.4225
Abstract: Key Points Question Do individuals with generalized anxiety disorder (GAD) show abnormal physiological, perceptual, or neural responses during peripheral β-adrenergic stimulation that may indicate interoceptive dysfunction? Findings In this crossover randomized clinical trial, female patients… read more here.
Keywords: ventromedial prefrontal; adrenergic stimulation; generalized anxiety; prefrontal cortex ... See more keywords
Impaired adrenergic agonist‐dependent beige adipocyte induction in aged mice
Sign Up to like & getrecommendations! Published in 2017 at "Obesity"
DOI: 10.1002/oby.21727
Abstract: There are two types of thermogenic adipocytes expressing uncoupling protein (UCP)−1: the brown adipocyte activated by adrenergic stimulation and the beige adipocyte that appears within the white adipose tissue (WAT) in response to chronic adrenergic… read more here.
Keywords: adrenergic agonist; adipocyte; adrenergic stimulation; impaired adrenergic ... See more keywords
Anti-inflammatory effect of β2 adrenergic stimulation on circulating monocytes with a pro-inflammatory state in high-fat diet-induced obesity
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.04.042
Abstract: Obesity is a chronic condition associated with low-grade inflammation, and it also involves alterations of the function of the hypothalamic-pituitaryadrenal axis and the sympathetic nervous system. Adrenergic agonists such as catecholamines are important immunoregulatory molecules… read more here.
Keywords: inflammatory state; adrenergic stimulation; high fat; obesity ... See more keywords
Oil Exposure Impairs In Situ Cardiac Function in Response to β-Adrenergic Stimulation in Cobia (Rachycentron canadum).
Sign Up to like & getrecommendations! Published in 2017 at "Environmental science & technology"
DOI: 10.1021/acs.est.7b03820
Abstract: Aqueous crude oil spills expose fish to varying concentrations of dissolved polycyclic aromatic hydrocarbons (PAHs), which can have lethal and sublethal effects. The heart is particularly vulnerable in early life stages, as PAH toxicity causes… read more here.
Keywords: cardiac function; adrenergic stimulation; exposure; oil exposure ... See more keywords
Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.02.18.481024
Abstract: Ryanodine Receptors (RyRs) exhibit dynamic arrangements in cardiomyocytes, and we previously showed that “dispersion” of RyR clusters disrupts Ca2+ homeostasis during heart failure (HF) (Kolstad et al., eLife, 2018). Here, we investigated whether prolonged β-adrenergic… read more here.
Keywords: ryr; dispersion; adrenergic stimulation; pathology ... See more keywords
β-Adrenergic stimulation induces pro-arrhythmic activity in the caval vein myocardial tissue
Sign Up to like & getrecommendations! Published in 2017 at "Doklady Biological Sciences"
DOI: 10.1134/s0012496617050027
Abstract: Electrical activity of the right superior vena cava (SVC) is considered as a source of the atrial fibrillation. We have shown that bioelectrical properties of the SVC myocardium differ from those of the working atrial… read more here.
Keywords: pro arrhythmic; adrenergic stimulation; stimulation induces; induces pro ... See more keywords
Altered K+ current profiles underlie cardiac action potential shortening in hyperkalemia and β adrenergic stimulation.
Sign Up to like & getrecommendations! Published in 2019 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2019-0056
Abstract: Hyperkalemia is known to develop in various conditions including vigorous physical exercise. In the heart, hyperkalemia is associated with action potential (AP) shortening that was attributed to altered gating of K+ channels. However, it remains… read more here.
Keywords: potential shortening; stimulation; adrenergic stimulation; hyperkalemia ... See more keywords
Nuclear receptor subfamily 4 group A member 2 inhibits activation of ERK signaling and cell growth in response to β-adrenergic stimulation in adult rat cardiomyocytes
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Physiology - Cell Physiology"
DOI: 10.1152/ajpcell.00526.2018
Abstract: Sustained elevation of sympathetic activity is an important contributor to pathological cardiac hypertrophy, ventricular arrhythmias, and left ventricular contractile dysfunction in chronic heart failure. The orphan nuclear receptor NR4A2 is an immediate early-response gene activated… read more here.
Keywords: cell; response; stimulation; adrenergic stimulation ... See more keywords
The lipidome of primary murine white, brite, and brown adipocytes—Impact of beta-adrenergic stimulation
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3000412
Abstract: Lipid species patterns are conserved within cells to maintain physicochemical properties of membranes and cellular functions. We present the lipidome, including sterols, glycerolipids (GLs), glycerophospholipids (GPLs), and sphingolipids (SLs), of primary ex vivo differentiated (I)… read more here.
Keywords: brown; adrenergic stimulation; brite brown; brown adipocytes ... See more keywords
Adaptive versus maladaptive cardiac remodelling in response to sustained β-adrenergic stimulation in a new ‘ISO on/off model’
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0248933
Abstract: On the one hand, sustained β-adrenergic stress is a hallmark of heart failure (HF) and exerts maladaptive cardiac remodelling. On the other hand, acute β-adrenergic stimulation maintains cardiac function under physiological stress. However, it is… read more here.
Keywords: iso model; iso; sustained adrenergic; cardiac remodelling ... See more keywords
The role of β-adrenergic stimulation in QT interval adaptation to heart rate during stress test
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0280901
Abstract: The adaptation lag of the QT interval after heart rate (HR) has been proposed as an arrhythmic risk marker. Most studies have quantified the QT adaptation lag in response to abrupt, step-like changes in HR… read more here.
Keywords: adaptation lag; adaptation; adrenergic stimulation; stimulation ... See more keywords