Heteromerization between α1B‐adrenoceptor and chemokine (C‐C motif) receptor 2 biases α1B‐adrenoceptor signaling: Implications for vascular function
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14463
Abstract: Previously, we reported that chemokine (C‐C motif) receptor 2 (CCR2) heteromerizes with α1B‐adrenoceptor (α1B‐AR) in leukocytes, through which α1B‐AR controls CCR2. Whether such heteromers are expressed in human vascular smooth muscle cells (hVSMCs) is unknown.… read more here.
Keywords: adrenoceptor; ccr2; chemokine motif; motif receptor ... See more keywords
Metabolic benefits of 1-(3-(4-(o-tolyl)piperazin-1-yl)propyl)pyrrolidin-2-one: a non-selective α-adrenoceptor antagonist
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-017-0779-7
Abstract: PurposePrevious studies have shown that several components of the metabolic syndrome, such as hypertension, obesity or imbalanced lipid and carbohydrate homeostasis, are associated with the sympathetic nervous system overactivity. Therefore, the inhibition of the adrenergic… read more here.
Keywords: non selective; pyrrolidin one; adrenoceptor; selective adrenoceptor ... See more keywords
Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central α2A adrenoceptor
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.10.008
Abstract: Sepsis-associated encephalopathy (SAE) is a significant clinical issue that is associated with increased mortality and cost of health care. Dexmedetomidine, an α2 adrenoceptor agonist that is used to provide sedation, has been shown to induce… read more here.
Keywords: clp; inflammation; sepsis associated; dexmedetomidine ... See more keywords
Complex Formation between VEGFR2 and the β2-Adrenoceptor
Sign Up to like & getrecommendations! Published in 2019 at "Cell Chemical Biology"
DOI: 10.1016/j.chembiol.2019.02.014
Abstract: Summary Vascular endothelial growth factor (VEGF) is an important mediator of endothelial cell proliferation and angiogenesis via its receptor VEGFR2. A common tumor associated with elevated VEGFR2 signaling is infantile hemangioma that is caused by… read more here.
Keywords: formation vegfr2; complex formation; vegfr2 adrenoceptor; adrenoceptor ... See more keywords
Cortical adrenoceptor expression, function and adaptation under conditions of cannabinoid receptor deletion
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2017.03.010
Abstract: ABSTRACT A neurochemical target at which cannabinoids interact to have global effects on behavior is brain noradrenergic circuitry. Acute and repeated administration of a cannabinoid receptor synthetic agonist is capable of increasing multiple indices of… read more here.
Keywords: mpfc; agr adrenoceptor; cannabinoid receptor; expression ... See more keywords
Selective activation of adrenoceptors potentiates IKs current in pulmonary vein cardiomyocytes through the protein kinase A and C signaling pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2021.08.004
Abstract: Delayed rectifier K+ current (IKs) is a key contributor to repolarization of action potentials. This study investigated the mechanisms underlying the adrenoceptor-induced potentiation of IKs in pulmonary vein cardiomyocytes (PVC). PVC were isolated from guinea… read more here.
Keywords: iks current; pulmonary vein; activation; protein kinase ... See more keywords
Discovery of a Highly Selective β2-Adrenoceptor Agonist with a 2-Amino-2-phenylethanol Scaffold as an Oral Antiasthmatic Agent.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02006
Abstract: Asthma patients in resource-poor countries cannot obtain adequate basic asthma medications because most asthma medications are supplied as inhalants. An alternative approach is to create oral antiasthmatic drugs with high β2/β1-selectivity, which should reduce treatment… read more here.
Keywords: antiasthmatic agent; oral antiasthmatic; adrenoceptor; amino phenylethanol ... See more keywords
PT-31, a putative α2-adrenoceptor agonist, is effective in schizophrenia cognitive symptoms in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000494
Abstract: Evidence of changes in central noradrenergic activity has been reported in schizophrenic patients and studies indicate that activation of the α2-adrenoceptor improves memory and neuroprotection. In this study, a new imidazolidine derivative 3-(2-chloro-6-fluorobenzyl)-imidazolidine-2,4-dione, PT-31, a… read more here.
Keywords: cognitive symptoms; memory; putative adrenoceptor; adrenoceptor ... See more keywords
What makes the α1A‐adrenoceptor gene product assume an α1L‐adrenoceptor phenotype?
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14599
Abstract: The α1A‐adrenoceptor is abundantly expressed in the lower urinary tract and is the principal therapeutic target for the symptomatic treatment of lower urinary tract symptoms in men. Prazosin has a lower affinity for the lower… read more here.
Keywords: urinary tract; adrenoceptor gene; pharmacology; adrenoceptor ... See more keywords
α-adrenoceptor stimulation attenuates melanoma growth in mice.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of pharmacology"
DOI: 10.1111/bph.15731
Abstract: BACKGROUND AND PURPOSE Recently, β-adrenoceptor blockade has emerged as a potential strategy to inhibit melanoma growth. However, it remains to be ascertained whether β-adrenoceptor stimulation by circulating catecholamines increases melanoma growth in mice. EXPERIMENTAL APPROACH… read more here.
Keywords: melanoma growth; growth mice; stimulation; adrenoceptor ... See more keywords
β2‐Adrenoceptor agonist profiling reveals biased signalling phenotypes for the β2‐adrenoceptor with possible implications for the treatment of asthma
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15900
Abstract: β‐Adrenoceptor agonists relieve airflow obstruction by activating β2‐adrenoceptors, which are G protein‐coupled receptors (GPCRs) expressed on human airway smooth muscle (HASM) cells. The currently available β‐adrenoceptor agonists are balanced agonists, however, and signal through both… read more here.
Keywords: adrenoceptor agonist; agonist profiling; profiling reveals; asthma ... See more keywords