Effect of β3‐adrenoceptor agonist on the micromotion of bilateral major pelvic ganglion‐excised rat bladder
Sign Up to like & getrecommendations! Published in 2023 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.25127
Abstract: Micromotion is an autonomous intramural movement of the bladder, and is believed to be an initial step in the generation of urinary urgency. Therefore, controlling micromotion may be a novel target in overactive bladder (OAB)… read more here.
Keywords: micromotion; bladder; adrenoceptor agonist; effect adrenoceptor ... See more keywords
Electrochemical sensors for β-adrenoceptor agonist isoprenaline analysis in human urine and serum samples using manganese cobalt oxide-modified glassy carbon electrode
Sign Up to like & getrecommendations! Published in 2021 at "New Journal of Chemistry"
DOI: 10.1039/d1nj01009c
Abstract: Schematic illustration for the synthesis of the MCO nanosphere and modification with GCE towards the electrochemical determination of isoprenaline. read more here.
Keywords: isoprenaline analysis; agonist isoprenaline; analysis human; electrochemical sensors ... See more keywords
The β2-adrenoceptor agonist clenbuterol reduces the neuroinflammatory response, neutrophil infiltration and apoptosis following intra-striatal IL-1β administration to rats
Sign Up to like & getrecommendations! Published in 2018 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2017.1418882
Abstract: Abstract Objectives: Clenbuterol is a brain penetrant β2-adrenoceptor agonist with anti-inflammatory and putative neuroprotective properties. In the present investigation, the effect of clenbuterol was assessed in a rat model of acute brain injury induced by… read more here.
Keywords: administration; response; infiltration; adrenoceptor agonist ... See more keywords
PT-31, a putative α2-adrenoceptor agonist, is effective in schizophrenia cognitive symptoms in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000494
Abstract: Evidence of changes in central noradrenergic activity has been reported in schizophrenic patients and studies indicate that activation of the α2-adrenoceptor improves memory and neuroprotection. In this study, a new imidazolidine derivative 3-(2-chloro-6-fluorobenzyl)-imidazolidine-2,4-dione, PT-31, a… read more here.
Keywords: cognitive symptoms; memory; putative adrenoceptor; adrenoceptor ... See more keywords
β2‐Adrenoceptor agonist profiling reveals biased signalling phenotypes for the β2‐adrenoceptor with possible implications for the treatment of asthma
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15900
Abstract: β‐Adrenoceptor agonists relieve airflow obstruction by activating β2‐adrenoceptors, which are G protein‐coupled receptors (GPCRs) expressed on human airway smooth muscle (HASM) cells. The currently available β‐adrenoceptor agonists are balanced agonists, however, and signal through both… read more here.
Keywords: adrenoceptor agonist; agonist profiling; profiling reveals; asthma ... See more keywords
A novel tissue-selective β2-adrenoceptor agonist with minimized cardiovascular effects, 5-HOB, attenuates neuropathic pain in mice
Sign Up to like & getrecommendations! Published in 2019 at "BMC Research Notes"
DOI: 10.1186/s13104-019-4466-y
Abstract: Objective5-HOB is a novel tissue selective, 5-hydroxybenzothiazolone-derived β2 adrenoceptor agonist with minimized cardiovascular effects while retaining efficacy on skeletal muscle in preclinical experiments unlike conventional β2 adrenoceptor agonists, however its effect on the nervous system… read more here.
Keywords: adrenoceptor agonist; novel tissue; neuropathic pain; adrenoceptor ... See more keywords
β3 adrenoceptor agonist mirabegron protects against right ventricular remodeling and drives Drp1 inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular Diagnosis and Therapy"
DOI: 10.21037/cdt-22-274
Abstract: Background The right ventricular (RV) function determines the prognosis of patients with pulmonary hypertension (PH). Metabolic disorders have been observed in the RV myocardium in PH. Activation of the β3 adrenoceptor improves cardiac function and… read more here.
Keywords: adrenoceptor agonist; adrenoceptor; right ventricular; drp1 inhibition ... See more keywords
Rosiglitazone and a β3-Adrenoceptor Agonist Are Both Required for Functional Browning of White Adipocytes in Culture
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2018.00249
Abstract: The recruitment of brite (or beige) adipocytes has been advocated as a means to combat obesity, due to their ability to phenotypically resemble brown adipocytes (BA). Lineage studies indicate that brite adipocytes are formed by… read more here.
Keywords: white adipocytes; adrenoceptor agonist; rosiglitazone adrenoceptor; rosiglitazone ... See more keywords