Sulfate radical induced degradation of β2-adrenoceptor agonists salbutamol and terbutaline: Phenoxyl radical dependent mechanisms.
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DOI: 10.1016/j.watres.2017.07.025
Abstract: The present study investigated the reactivity and oxidation mechanisms of salbutamol (SAL) and terbutaline (TBL), two typical β2-adrenoceptor agonists, towards sulfate radical (SO4-) by using photo-activated persulfate (PS). The reaction pathways and mechanisms were proposed… read more here.
Keywords: degradation; sulfate radical; phenoxyl; adrenoceptor agonists ... See more keywords
β2‐Adrenoceptor agonist profiling reveals biased signalling phenotypes for the β2‐adrenoceptor with possible implications for the treatment of asthma
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DOI: 10.1111/bph.15900
Abstract: β‐Adrenoceptor agonists relieve airflow obstruction by activating β2‐adrenoceptors, which are G protein‐coupled receptors (GPCRs) expressed on human airway smooth muscle (HASM) cells. The currently available β‐adrenoceptor agonists are balanced agonists, however, and signal through both… read more here.
Keywords: adrenoceptor agonist; agonist profiling; profiling reveals; asthma ... See more keywords
Analysis of Urinary Retention Caused by Selective β 3-adrenoceptor Agonists Using the Japanese Adverse Drug Event Report Database (JADER).
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DOI: 10.1691/ph.2023.3509
Abstract: Overactive bladder (OAB) is a frequent chronic disorder which impairs quality of life by frequent, uncontrollable urination. Newly developed selectiveβ 3-adrenoceptor agonists (sβ 3-agonists) have the same efficacy in treating OAB but significantly fewer side… read more here.
Keywords: retention; jader; selective adrenoceptor; adrenoceptor agonists ... See more keywords
Drugs Showing Real-world Efficacy for Nocturia in Patients With Bladder Storage Symptoms
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DOI: 10.21873/anticanres.16182
Abstract: Background/Aim: Nocturia is defined as the symptom that an individual has to disrupt their sleep at night, for one or several times, in order to void. Nocturia is a bothersome event that markedly reduces a… read more here.
Keywords: storage symptoms; anticholinergic drugs; adrenoceptor agonists; drugs adrenoceptor ... See more keywords
A Clinician’s Perspective on the Mechanism of β3-Adrenoceptor Agonists in the Bladder
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DOI: 10.5213/inj.1720edi001
Abstract: Copyright © 2017 Korean Continence Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium,… read more here.
Keywords: mechanism adrenoceptor; agonists bladder; adrenoceptor agonists; perspective mechanism ... See more keywords