Adipokine and cytokine levels in patients with adrenocortical cancer, subclinical Cushing's syndrome and healthy controls
Sign Up to like & getrecommendations! Published in 2018 at "Steroids"
DOI: 10.1016/j.steroids.2018.08.011
Abstract: Introduction: In recent years researchers have focused at hormonal activity in Cushing's syndrome (CS) in connection with metabolic disorders and the role of adipokines and cytokines secreted by the adipose tissue. The aim of the… read more here.
Keywords: cytokine; cytokine levels; adipokine cytokine; cushing syndrome ... See more keywords
Whole-genome and transcriptome analysis of advanced adrenocortical cancer highlights multiple alterations affecting epigenome and DNA repair pathways
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor Molecular Case Studies"
DOI: 10.1101/mcs.a006148
Abstract: Adrenocortical cancer (ACC) is a rare cancer of the adrenal gland. Several driver mutations have been identified in both primary and metastatic ACCs, but the therapeutic options are still limited. We performed whole-genome and transcriptome… read more here.
Keywords: whole genome; alterations affecting; genome transcriptome; analysis ... See more keywords
Adrenocortical cancer cell line mutational profile reveals aggressive genetic background.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-18-0262
Abstract: Adrenocortical carcinomas are rare tumors with poor prognosis and limited treatment options. Although widely used as in vitro models to test novel therapeutic strategies, the adrenocortical carcinoma-derived cell lines NCI-H295R and SW-13 have been only… read more here.
Keywords: nci h295r; adrenocortical cancer; cell; adrenocortical carcinoma ... See more keywords
New insights in the clinical and translational relevance of miR483-5p in adrenocortical cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19118
Abstract: Adrenocortical cancer (ACC) is a rare aggressive malignancy. Recent ACC integrated genomics analysis contributed to redefine the risk groups on molecular basis, including tumor microRNAs (miRs), detectable also in the bloodstream. We developed a quantitative… read more here.
Keywords: mir483; mir483 mir483; new insights; mir483 levels ... See more keywords
Prognostic factors and mitotane treatment of adrenocortical cancer. Two decades of experience from an institutional case series
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.952418
Abstract: Objectives This study aimed to characterise the clinicopathological features and prognostic factors of a large cohort of Hungarian patients with adrenocortical cancer diagnosed between 2000-2021. Patients and methods This retrospective study included seventy-four patients (27… read more here.
Keywords: prognostic factors; overall survival; resection; adrenocortical cancer ... See more keywords
Complete Remission of Advanced Adrenocortical Cancer Following Mitotane Monotherapy: A Case Report and Literature Review of Predictive Markers
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.680853
Abstract: Mitotane has been used for the treatment of adrenocortical cancer (ACC) for over 50 years. Despite its widespread use both in monotherapy and in combination with chemotherapeutics, our knowledge of its mechanism of action and… read more here.
Keywords: complete remission; mitotane; remission; mitotane monotherapy ... See more keywords
Interplay between Immune Cell Infiltration and Tumor Histological Subtype: A Case of Adrenocortical Cancer
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DOI: 10.3390/cancers14215303
Abstract: Simple Summary The interplay between histological subtype and tumor microenvironment, especially the presence of tumor-infiltrating immune cells (TIIC), in adrenocortical cancer remains unclear. Here, we perform a comparative analysis of TIIC composition in conventional and… read more here.
Keywords: infiltration; endocrinology; adrenocortical cancer; immune ... See more keywords