FSCN1 as a new druggable target in adrenocortical carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Cancer"
DOI: 10.1002/ijc.34526
Abstract: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatic spread. The actin‐bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has… read more here.
Keywords: new druggable; druggable target; acc; adrenocortical carcinoma ... See more keywords
Ferroptosis‐based molecular prognostic model for adrenocortical carcinoma based on least absolute shrinkage and selection operator regression
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24465
Abstract: This study aimed to find ferroptosis‐related genes linked to clinical outcomes of adrenocortical carcinoma (ACC) and assess the prognostic value of the model. read more here.
Keywords: ferroptosis based; based molecular; model; adrenocortical carcinoma ... See more keywords
Contemporary conditional cancer‐specific survival rates in surgically treated adrenocortical carcinoma patients: A stage‐specific analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.27161
Abstract: We examined the effect of disease‐free interval (DFI) duration on cancer‐specific mortality (CSM)‐free survival, otherwise known as the effect of conditional survival, in surgically treated adrenocortical carcinoma (ACC) patients. read more here.
Keywords: surgically treated; survival; treated adrenocortical; cancer specific ... See more keywords
Positive Lymph Nodes in Adrenocortical Carcinoma: What Does It Mean?
Sign Up to like & getrecommendations! Published in 2020 at "World Journal of Surgery"
DOI: 10.1007/s00268-020-05801-x
Abstract: Background The role of lymphadenectomy in adrenocortical carcinoma resection is controversial. Therefore, we conducted a population-based study to assess the association between positive lymph nodes (LN) and survival. Methods The Surveillance, Epidemiology, and End Results… read more here.
Keywords: adrenocortical carcinoma; resection; lymph nodes; positive lymph ... See more keywords
SIRT6 abrogation promotes adrenocortical carcinoma through activation of NF-κB signaling
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03525-8
Abstract: As an uncommon malignancy in the adrenal gland, adrenocortical carcinoma (ACC) is characterized by thorny diagnosis and poor clinical outcome, necessitating innovative treatment strategies. Sirtuin 6 (SIRT6), a tumor suppressor, modulates aerobic glycolysis of malignant… read more here.
Keywords: adrenocortical carcinoma; carcinoma; abrogation promotes; sirt6 knockdown ... See more keywords
Informing therapeutic lymphadenectomy: Location of regional metastatic lymph nodes in adrenocortical carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of surgery"
DOI: 10.1016/j.amjsurg.2021.10.014
Abstract: BACKGROUND The anatomic boundaries of lymphadenectomy for adrenocortical carcinoma (ACC) are not defined. METHODS Adults undergoing resection of ACC were included. Locations were categorized based on positive LN locations on final pathology. RESULTS Of 231… read more here.
Keywords: adrenocortical carcinoma; renal hilar; para aortic; left renal ... See more keywords
Early progression under mitotane and polychemotherapy does not mean failure in adrenocortical carcinoma patient.
Sign Up to like & getrecommendations! Published in 2017 at "Annales d'endocrinologie"
DOI: 10.1016/j.ando.2016.10.001
Abstract: A 52-year-old female underwent surgery in March 2009 or a localized non-secretory adrenocortical carcinoma (ACC) f 17 cm. A Weiss score of 9 with a mitotic rate of more han 5/50HPF and a Ki67 of… read more here.
Keywords: adrenocortical carcinoma; mitotane; early progression; response ... See more keywords
Medical management of adrenocortical carcinoma: current recommendations, new therapeutic options and future perspectives.
Sign Up to like & getrecommendations! Published in 2020 at "Annales d'endocrinologie"
DOI: 10.1016/j.ando.2020.12.003
Abstract: Adrenocortical carcinoma is a rare malignant tumor of poor prognosis, frequently requiring additional treatments after initial surgery. Due to its adrenolytic action, Mitotane has become the first line medical treatment in patients with aggressive adrenocortical… read more here.
Keywords: adrenocortical carcinoma; carcinoma; management adrenocortical; medical management ... See more keywords
Stage Presentation, Care Patterns, Treatment Outcomes, and Impact of Radiotherapy on Overall Survival for Adrenocortical Carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical genitourinary cancer"
DOI: 10.1016/j.clgc.2021.03.009
Abstract: INTRODUCTION Adrenocortical carcinoma (ACC) is a rare cancer with few well-powered studies regarding epidemiology or outcomes and even fewer studies to guide an evidence-based management approach. The effect of radiation therapy (RT) is particularly understudied… read more here.
Keywords: adrenocortical carcinoma; care patterns; epidemiology; overall survival ... See more keywords
Adrenocortical Carcinoma with Hypercortisolism.
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology and metabolism clinics of North America"
DOI: 10.1016/j.ecl.2018.02.003
Abstract: Adrenocortical carcinoma (ACC) is a rare and aggressive tumor. ACC may be associated with different syndromes of hormone excess, most frequently Cushing's syndrome with or without hypersecretion of androgens. Recent data suggest that cortisol excess… read more here.
Keywords: adrenocortical carcinoma; acc; carcinoma hypercortisolism; endocrinology ... See more keywords
Phase II study of cabazitaxel as second-third line treatment in patients with metastatic adrenocortical carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "ESMO open"
DOI: 10.1016/j.esmoop.2022.100422
Abstract: BACKGROUND Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with a poor prognosis. No efficacious treatment options are currently available for patients with advanced metastatic disease with disease progression to standard etoposide, doxorubicin, cisplatin… read more here.
Keywords: second third; adrenocortical carcinoma; treatment; line ... See more keywords