Clinical characteristics and prognosis of adrenocortical tumors in children
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Surgery International"
DOI: 10.1007/s00383-018-4409-z
Abstract: PurposeThe purpose of this study was to review the clinical characteristics and prognosis of children with adrenocortical tumors (ACT).MethodsWe retrospectively reviewed the medical records of 28 patients with ACT at our hospital between March 2010… read more here.
Keywords: prognosis adrenocortical; tumors children; characteristics prognosis; adrenocortical tumors ... See more keywords
Is there a role for epithelial-mesenchymal transition in adrenocortical tumors?
Sign Up to like & getrecommendations! Published in 2017 at "Endocrine"
DOI: 10.1007/s12020-017-1409-z
Abstract: PurposeEpithelial-mesenchymal transition (EMT) is a biological dynamic process by which epithelial cells lose their epithelial phenotype and acquire mesenchymal invasive and migratory characteristics. This has been postulated as an essential step during cancer progression and… read more here.
Keywords: twist1 sip1; mesenchymal transition; expression; role ... See more keywords
Clinicopathological description of 43 oncocytic adrenocortical tumors: importance of Ki-67 in histoprognostic evaluation
Sign Up to like & getrecommendations! Published in 2018 at "Modern Pathology"
DOI: 10.1038/s41379-018-0077-8
Abstract: Oncocytic adrenocortical tumors are a rare subtype of adrenal tumors with challenging diagnosis and histoprognostic assessment. It is usually believed that oncocytic adrenocortical tumors have a more indolent clinical behavior than conventional adrenocortical tumors. As… read more here.
Keywords: description oncocytic; oncocytic adrenocortical; tumors importance; adrenocortical tumors ... See more keywords
Plant Natural Compounds in the Treatment of Adrenocortical Tumors
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Endocrinology"
DOI: 10.1155/2021/5516285
Abstract: Plant natural products are a plethora of diverse and complex molecules produced by the plant secondary metabolism. Among these, many can reserve beneficial or curative properties when employed to treat human diseases. Even in cancer,… read more here.
Keywords: natural compounds; plant; plant natural; compounds treatment ... See more keywords
IDH1 Expression via the R132H Mutation–Specific Antibody in Adrenocortical Neoplasias—Prognostic Impact in Carcinomas
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DOI: 10.1210/jendso/bvaa018
Abstract: Abstract Context Mutations to isocitrate dehydrogenase (IDH) appear to play a prognostic or predictive role in several neoplasias. Immunohistochemical staining designed to detect a specific R132H mutation to IDH1 showed expression in the normal adrenal… read more here.
Keywords: carcinomas; staining; adrenocortical tumors; r132h mutation ... See more keywords
Tumor DNA Methylation Profiling Is a Robust and Independent Prognostic Marker for Pediatric Patients With Adrenocortical Tumors
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvab048.200
Abstract: Pediatric adrenocortical tumors (pACTs) display complex genomic background and lack robust prognostic biomarkers. However, pACT methylation profiling was recently associated with patient prognosis. In order to evaluate whether tumor DNA methylation is associated with patient… read more here.
Keywords: profiling robust; adrenocortical tumors; tumor dna; methylation ... See more keywords
Pediatric adrenocortical tumors cohort characteristics and long-term follow-up at a single Argentinian tertiary center
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pediatric Endocrinology and Metabolism"
DOI: 10.1515/jpem-2021-0392
Abstract: Abstract Pediatric adrenocortical tumors are rare and heterogeneous endocrine malignancies. Objectives To report clinical, biochemical, and histological features, staging, and therapeutic interventions in a cohort of 28 patients treated at a single tertiary center. Methods… read more here.
Keywords: tertiary center; adjuvant chemotherapy; pediatric adrenocortical; adrenocortical tumors ... See more keywords
Gonadotropin-dependent pubertal disorders are common in patients with virilizing adrenocortical tumors in childhood
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine Connections"
DOI: 10.1530/ec-19-0141
Abstract: Objective To investigate the impact of early exposure to androgen excess on gonadotropin-dependent puberty (GDP) and final height (FH) of patients with androgen-secreting adrenocortical tumors (ACT) in childhood. Methods Retrospective cohort study. Occurrence of GDP… read more here.
Keywords: pubertal disorders; pubertal; adrenocortical tumors; dependent pubertal ... See more keywords
DNA methylation is a comprehensive marker for pediatric adrenocortical tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine-related cancer"
DOI: 10.1530/erc-22-0145
Abstract: Children diagnosed with adrenocortical tumors (pACT) have variable outcomes and, to date, the disease lacks robust prognostic biomarkers. The prognostic potential of tumor methylation has been demonstrated in several cancers. We aimed to evaluate the… read more here.
Keywords: methylation; adrenocortical tumors; tumor methylation; disease ... See more keywords
Next-generation sequencing reveals microRNA markers of adrenocortical tumors malignancy
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DOI: 10.18632/oncotarget.16788
Abstract: Background Adrenocortical carcinoma is a rare finding among common adrenocortical tumors, but it is highly aggressive and requires early detection and treatment. Still, the differential diagnosis between benign and malignant lesions is difficult even for… read more here.
Keywords: malignancy; adrenocortical tumors; mir 483; next generation ... See more keywords
TCF21/POD-1, a Transcritional Regulator of SF-1/NR5A1, as a Potential Prognosis Marker in Adult and Pediatric Adrenocortical Tumors
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2018.00038
Abstract: With recent progress in understanding the pathogenesis of adrenocortical tumors (ACTs), identification of molecular markers to predict their prognosis has become possible. Transcription factor 21 (TCF21)/podocyte-expressed 1 (POD1) is a transcriptional regulatory protein expressed in… read more here.
Keywords: adult; bub1b; tcf21 pod; expression ... See more keywords