Thrombin rapidly digests adrenomedullin: Synthesis of adrenomedullin analogs resistant to thrombin.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.057
Abstract: Human adrenomedullin (AM) functions as a circulating hormone and as a local paracrine mediator with multiple biological activities. We investigated the metabolism of AM by examining its fragmentation in human serum. Adrenomedullin was rapidly cleaved… read more here.
Keywords: resistant thrombin; analogs resistant; adrenomedullin; rapidly digests ... See more keywords
CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02293-w
Abstract: Agonist bias occurs when different ligands produce distinct signalling outputs when acting at the same receptor. However, its physiological relevance is not always clear. Using primary human cells and gene editing techniques, we demonstrate endogenous… read more here.
Keywords: agonist; adrenomedullin; agonist bias; receptor ... See more keywords
Bioactive Adrenomedullin, Organ Support Therapies, and Survival in the Critically Ill: Results from the French and European Outcome Registry in ICU Study.
Sign Up to like & getrecommendations! Published in 2019 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000004044
Abstract: OBJECTIVES Adrenomedullin has vascular properties and elevated plasma adrenomedullin levels were detected in sepsis. We assessed, in septic and nonseptic ICU patients, the relation between circulating adrenomedullin, the need for organ support and mortality, using… read more here.
Keywords: adrenomedullin; organ support; physiology; icu ... See more keywords
Increased concentrations of bioactive adrenomedullin subsequently to angiotensin‐receptor/neprilysin‐inhibitor treatment in chronic systolic heart failure
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.14442
Abstract: The clinically investigated rationale for neprilysin (NEP)‐inhibition by angiotensinreceptor‐NEPinhibitor (ARNi) therapy is to induce elevations in endogenous natriuretic peptides. NEP, however, cleaves a broad spectrum of substrates, which partially hold significant implications in heart failure… read more here.
Keywords: concentrations bioactive; heart; increased concentrations; adrenomedullin ... See more keywords
The value of plasma pro-enkephalin and adrenomedullin for the prediction of sepsis-associated acute kidney injury in critically ill patients
Sign Up to like & getrecommendations! Published in 2020 at "Critical Care"
DOI: 10.1186/s13054-020-02887-6
Abstract: Kidney function is commonly affected by sepsis, which is one of the most prominent causes of acute kidney injury (AKI) [1]. Seeking early, reliable biomarkers for the detection of AKI in critically ill patients with… read more here.
Keywords: sepsis; kidney injury; value; adrenomedullin ... See more keywords
Adrenomedullin and its receptors are expressed in mouse pancreatic β-cells and suppresses insulin synthesis and secretion
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0265890
Abstract: Gestational diabetes mellitus (GDM) is associated with defective pancreatic β-cell adaptation in pregnancy, but the underlying mechanism remains obscure. Our previous studies demonstrated that GDM women display increased plasma adrenomedullin (ADM) levels, and non-obese GDM… read more here.
Keywords: mouse pancreatic; adrenomedullin; secretion; receptors expressed ... See more keywords
Oocyte-specific disruption of adrenomedullin 2 gene enhances ovarian follicle growth after superovulation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1047498
Abstract: Background Adrenomedullin 2 (ADM2), adrenomedullin (ADM), and calcitonin gene-related peptides (α- and β-CGRPs) signal through heterodimeric calcitonin receptor-like receptor/receptor activity-modifying protein 1, 2 and 3 (CLR/RAMP1, 2 and 3) complexes. These peptides are important regulators… read more here.
Keywords: superovulation; disruption; adm2; oocyte specific ... See more keywords
Effects of Adrenomedullin on Atrial Electrophysiology and Pulmonary Vein Arrhythmogenesis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214064
Abstract: Adrenomedullin, a peptide with vasodilatory, natriuretic, and diuretic effects, may be a novel agent for treating heart failure. Heart failure is associated with an increased risk of atrial fibrillation (AF), but the effects of adrenomedullin… read more here.
Keywords: adrenomedullin atrial; arrhythmogenesis; effects adrenomedullin; pulmonary vein ... See more keywords