Structural equilibrium underlying ligand-dependent activation of β2-adrenoreceptor
Sign Up to like & getrecommendations! Published in 2020 at "Nature Chemical Biology"
DOI: 10.1038/s41589-019-0457-5
Abstract: G-protein-coupled receptors (GPCRs) are seven-transmembrane proteins mediating cellular signals in response to extracellular stimuli. Although three-dimensional structures showcase snapshots that can be sampled in the process and nuclear magnetic resonance detects conformational equilibria, the mechanism… read more here.
Keywords: adrenoreceptor; equilibrium; activation; equilibrium underlying ... See more keywords
MRI Assessment of Cardiomyopathy Induced by β1-Adrenoreceptor Autoantibodies and Protection Through β3-Adrenoreceptor Overexpression
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DOI: 10.1038/srep43951
Abstract: The cardiopathogenic role of autoantibodies (aabs) directed against β1-adrenoreceptors (β1-AR) is well established. In mouse models, they cause progressive dilated cardiomyopathy (DCM) whose characterization with echocardiography requires prolonged protocols with numerous animals, complicating the evaluation… read more here.
Keywords: induced adrenoreceptor; adrenoreceptor; assessment cardiomyopathy; adrenoreceptor autoantibodies ... See more keywords
The α1-adrenergic receptors in the amygdala regulate the induction of learned despair through protein kinase C-beta signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000605
Abstract: Hyperactivity of amygdala is observed in patients with major depressive disorder. Although the role of α1-adrenoceptor in amygdala on fear memory has been well studied, the role of α1-adrenoceptor in amygdala on depression-like behaviors remains… read more here.
Keywords: induction learned; protein kinase; despair; learned despair ... See more keywords
The Dual Role of the β2-Adrenoreceptor in the Modulation of IL-17 and IFN-γ Production by T Cells in Multiple Sclerosis
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DOI: 10.3390/ijms23020668
Abstract: Norepinephrine is a neurotransmitter that also has an immunomodulatory effect and is involved in multiple sclerosis (MS) pathogenesis. This study aimed to clarify the role of the β2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17)… read more here.
Keywords: ifn production; norepinephrine; adrenoreceptor; production ... See more keywords