Design, Synthesis and Evaluation of AdSS Bisubstrate Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "ChemMedChem"
DOI: 10.1002/cmdc.202000498
Abstract: Many cancers lack the expression of methylthioadenosine phosphorylase (MTAP). These cancers require adenylosuccinate synthetase (AdSS) for nucleic acid synthesis. By inhibiting adenylosuccinate synthetase, we potentially have a new therapeutic agent. Bisubstrate inhibitors were synthesized and… read more here.
Keywords: evaluation adss; design synthesis; bisubstrate inhibitors; adss ... See more keywords
P0696 ADSS: A novel AI-derived metric for quantifying disease severity and extent in ulcerative colitis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjae190.0870
Abstract: The Mayo Endoscopic Subscore (MES) is the prevailing standard for evaluating ulcerative colitis (UC) severity endoscopically, but correlates poorly with response to treatment. A comprehensive assessment encompassing both severity and extent is critical for monitoring… read more here.
Keywords: disease; disease severity; severity extent; severity ... See more keywords