ADT with antiandrogens in prostate cancer induces adverse effect of increasing resistance, neuroendocrine differentiation and tumor metastasis.
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DOI: 10.1016/j.canlet.2018.09.020
Abstract: Prostate cancer (PCa) is the most common cancer and the 2nd leading cause of cancer-related deaths among men in the United States. Androgen-deprivation-therapy (ADT) with antiandrogens to target the androgens/androgen receptor (AR) signals remains the… read more here.
Keywords: neuroendocrine differentiation; prostate cancer; resistance; cancer ... See more keywords