UMOD Mutations in Chronic Kidney Disease in Taiwan
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DOI: 10.3390/biomedicines10092265
Abstract: UMOD is the first identified and the most commonly mutated gene that causes autosomal dominant tubulointerstitial kidney disease (ADTKD). Recent studies have shown that ADTKD-UMOD is a relatively common cause of chronic kidney disease (CKD).… read more here.
Keywords: taiwan; kidney; chronic kidney; kidney disease ... See more keywords
Upregulation of C/EBP Homologous Protein induced by ER Stress Mediates Epithelial to Myofibroblast Transformation in ADTKD-UMOD
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DOI: 10.7150/ijms.65036
Abstract: Autosomal dominant tubulointerstitial kidney disease due to UMOD mutations (ADTKD-UMOD) results in chronic interstitial nephritis, which gradually develops into end-stage renal disease. It is believed that the accumulation of mutant uromodulin causes the endoplasmic reticulum… read more here.
Keywords: epithelial myofibroblast; chop; expression; myofibroblast transformation ... See more keywords